Publication Name	World Journal of Gastroenterology
Manuscript ID	120596
DOI	10.3748/wjg.120596
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Adenomatous polyposis coli promoter abnormalities in familial adenomatous polyposis and gastric adenocarcinoma and proximal polyposis of the stomach
Manuscript Source	Invited Manuscript
All Author List	Kenichi Taguchi, Masaya Iwamuro, Xueni Liu, Chikako Shibata, Seiji Kawano and Motoyuki Otsuka
Funding Agency and Grant Number	Funding Agency Grant Number Japan Society for the Promotion of Science KAKENHI No. JP25K10425 and No. JP25K22578
Corresponding Author	Masaya Iwamuro, Assistant Professor, MD, PhD, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Kita-Ku, Okayama 700-8558, Japan. pr145h2k@okayama-u.ac.jp
Key Words	Adenomatous polyposis coli; Promoter 1B; Familial adenomatous polyposis; Gastric adenocarcinoma and proximal polyposis of the stomach; Yin Yang 1; Deletion; Single-nucleotide variant
Core Tip	Abnormalities in the adenomatous polyposis coli promoter region are among the causes of familial adenomatous polyposis in patients without pathogenic variants in the coding region, as well as gastric adenocarcinoma and proximal polyposis of the stomach. In the present systematic review, the adenomatous polyposis coli promoter-region abnormalities were classified as follows: Deletions limited to promoter 1B; variants affecting the Yin Yang 1 (YY1) binding site; point variants outside the YY1 binding site; and large deletions or structural alterations encompassing the entire promoter-region. The variants affecting the YY1 binding site were further subclassified according to clinical phenotype.
Citation	Taguchi K, Iwamuro M, Liu X, Shibata C, Kawano S, Otsuka M. Adenomatous polyposis coli promoter abnormalities in familial adenomatous polyposis and gastric adenocarcinoma and proximal polyposis of the stomach. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.120596
PDF	120596-in-press.pdf

Received	2026-03-03 03:18
Peer-Review Started	2026-03-03 03:19
First Decision by Editorial Office Director	2026-03-20 11:31
Return for Revision	2026-03-20 11:31
Revised	2026-04-18 15:34
Publication Fee Transferred
Second Decision by Editor	2026-06-09 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-09 08:30
Articles in Press	2026-06-09 08:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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