Publication Name	World Journal of Clinical Oncology
Manuscript ID	120600
Country	Italy

Category	Medicine, General & Internal
Manuscript Type	Meta-Analysis
Article Title	Intracystic glucose is superior to carcinoembryonic antigen in diagnosing mucinous pancreatic cysts in genomic era: Systematic review and meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Giacomo Emanuele Maria Rizzo, Giuseppe Infantino, Giovanni Marchegiani, Jorge D Machicado, Marco Del Chiaro, Ilaria Tarantino, Gemma Rossi, Paolo Giorgio Arcidiacono, Giuseppe Vanella, Lucia Guilabert, Sara Nikolić and Gabriele Capurso
Funding Agency and Grant Number
Corresponding Author	Giacomo Emanuele Maria Rizzo, MD, PhD, Gastroenterology and Endoscopy Unit, Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT, UPMC Italy, Via Tricomi, 5, Palermo 90127, Sicilia, Italy. g.rizzo.gr@gmail.com
Key Words	Pancreas; Pancreatic cyst; Mucinous cyst; Intracystic glucose; Intracystic carcinoembryonic antigen; Genetic test
Core Tip	Accurate diagnosis of pancreatic cysts is fundamental for patient management. Intracystic glucose (IG), a simple and cost-effective marker, showed promising results compared to carcinoembryonic antigen (CEA) and emerging molecular markers. Nonetheless, low quality evidences and weak recommendation have been reported in the guidelines. In this study, sixteen studies showed glucose had higher accuracy [odd ratio (OR): 3.35] and sensitivity (OR: 9.36) than CEA, while CEA had greater specificity (OR: 0.43). These findings support the use of IG as a methodologically stable biomarker, particularly suitable as a rule-out test for mucinous cysts. Therefore, this study reinforces the role of IG as a first-line diagnostic biomarker in identifying mucinous pancreatic cysts. Physicians can easily use IG in identifying mucinous cysts with greater certainty.
Citation	Rizzo GEM, Infantino G, Marchegiani G, Machicado JD, Del Chiaro M, Tarantino I, Rossi G, Arcidiacono PG, Vanella G, Guilabert L, Nikolić S, Capurso G. Intracystic glucose is superior to carcinoembryonic antigen in diagnosing mucinous pancreatic cysts in genomic era: Systematic review and meta-analysis. World J Clin Oncol 2026; In press

Received	2026-03-03 01:52
Peer-Review Started	2026-03-03 01:52
First Decision by Editorial Office Director	2026-03-05 09:36
Return for Revision	2026-03-05 09:36
Revised	2026-03-14 20:46
Publication Fee Transferred	2026-03-20 08:02
Second Decision by Editor	2026-04-20 02:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-20 08:52
Articles in Press	2026-04-20 08:52
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Typeset the Manuscript

ISSN	2218-4333 (online)
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