Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	120610
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Association of severe thrombocytopenia with prognosis following transjugular intrahepatic portosystemic shunt in cirrhotic patients with portal hypertension
Manuscript Source	Unsolicited Manuscript
All Author List	Liu Zhang, Shi-Qi Xu, Yi-Jiang Zhu, Li Dong, Liang Yin, Jin-Chang Xiao, De-Lei Cheng, Rui-Feng Wang and Chun-Ze Zhou
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82370748 Scientific Research Foundation of the Education Department of Anhui Province No. 2022AH040189 Anhui Provincial Health Commission Scientific Research Project No. AHWJ2024Aa10141
Corresponding Author	Chun-Ze Zhou, Assistant Professor, MD, School of Graduate, Bengbu Medical University, No. 2600 Donghai Avenue, Bengbu 233030, Anhui Province, China. zhouchunze@ustc.edu.cn
Key Words	Thrombocytopenia; Transjugular intrahepatic portosystemic shunt; Portal hypertension; Liver cirrhosis; Prognosis
Core Tip	In this multicenter study of 434 cirrhotic patients, severe thrombocytopenia (< 50 × 109/L) was initially associated with poorer survival after transjugular intrahepatic portosystemic shunt (TIPS), but this association vanished after adjusting for liver disease severity using propensity score matching. Although severe thrombocytopenia correlated with an increased risk of minor bleeding, it was not linked to moderate-to-severe or procedural hemorrhage. These findings challenge conventional assumptions by demonstrating that baseline liver dysfunction, not platelet count, is the key driver of post-TIPS prognosis. Clinicians should therefore focus on comprehensive liver function evaluation rather than platelet thresholds when assessing TIPS candidates.
Citation	Zhang L, Xu SQ, Zhu YJ, Dong L, Yin L, Xiao JC, Cheng DL, Wang RF, Zhou CZ. Association of severe thrombocytopenia with prognosis following transjugular intrahepatic portosystemic shunt in cirrhotic patients with portal hypertension. World J Gastrointest Surg 2026; In press

Received	2026-03-04 03:19
Peer-Review Started	2026-03-04 03:22
First Decision by Editorial Office Director	2026-03-06 08:17
Return for Revision	2026-03-06 08:17
Revised	2026-03-20 08:06
Publication Fee Transferred	2026-03-25 08:21
Second Decision by Editor	2026-04-10 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-10 08:28
Articles in Press	2026-04-10 08:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com