Publication Name	World Journal of Diabetes
Manuscript ID	120647
DOI	10.4239/wjd.120647
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Observational Study
Article Title	Association between the high-sensitivity C-reactive protein-triglyceride-glucose index and metabolic dysfunction-associated steatotic liver disease across different glycemic states
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Hao Zhang, Rong-Dong-Qing Shi, Kui Chen, Xian-Ming Li, Gui-Hua Yu, Xin-Yuan Ye, Qing Xu, Yu Ding and Si-Hui Luo
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82300904 National Natural Science Foundation of China 82100857
Corresponding Author	Si-Hui Luo, Department of Endocrinology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 17 Lujiang Road, Hefei 230000, Anhui Province, China. luosihui@ustc.edu.cn
Key Words	Metabolic dysfunction-associated steatotic liver disease; High-sensitivity C-reactive protein-triglyceride-glucose index; Glycemic status; Prediabetes; Diabetes; Cross-sectional study
Core Tip	This large cross-sectional study (n = 7413) evaluated the high-sensitivity C-reactive protein-triglyceride-glucose index (CTI) as a non-invasive biomarker for metabolic dysfunction-associated steatotic liver disease (MASLD) across glycemic states. The CTI showed robust diagnostic performance (area under the curve: 0.808) with strongest predictive value in normal glucose regulation (adjusted OR = 3.07) and prediabetes (OR = 3.26), but weaker association in diabetes (OR = 1.58). Optimal CTI thresholds increased progressively from normoglycemia to diabetes (8.596, 8.908, 9.456, respectively). These findings suggest CTI is a practical biomarker for early MASLD risk identification, particularly in individuals without overt diabetes.
Citation	Zhang WH, Shi RDQ, Chen K, Li XM, Yu GH, Ye XY, Xu Q, Ding Y, Luo SH. Association between the high-sensitivity C-reactive protein-triglyceride-glucose index and metabolic dysfunction-associated steatotic liver disease across different glycemic states. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.120647
PDF	120647-in-press.pdf

Received	2026-03-05 00:26
Peer-Review Started	2026-03-05 23:55
First Decision by Editorial Office Director	2026-03-27 10:31
Return for Revision	2026-03-27 10:31
Revised	2026-04-09 08:51
Publication Fee Transferred	2026-04-13 02:59
Second Decision by Editor	2026-05-18 02:55
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-09 06:31
Articles in Press	2026-06-09 06:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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