Publication Name	World Journal of Psychiatry
Manuscript ID	120652
DOI	10.5498/wjp.120652
Country	Japan

Category	Psychiatry
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Insight into the nonlinear association between thyroid-stimulating hormone and suicide risk in first-episode major depressive disorder
Manuscript Source	Invited Manuscript
All Author List	Takahiko Nagamine
Funding Agency and Grant Number
Corresponding Author	Takahiko Nagamine, Sunlight Brain Research Center, Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, Hofu 747-0066, Japan; <email>tnagamine@outlook.com</email>; Tel.: +81-835-25-6610; Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Bunkyou 113-8510, Japan, <bold>Address for correspondence.</bold> Takahiko Nagamine, MD, PhD, Sunlight Brain Research Center, 4-13-18 Jiyugaoka, Hofu City, Yamaguchi, 747-0066, Japan; e-mail: <email xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">tnagamine@outlook.com</email>, Hofu 7470066, Yamaguchi, Japan. tnagamine@outlook.com
Key Words	Major depressive disorder; Thyroid-stimulating hormone; Suicide attempts; Sex differences; Metabolic markers; First-episode drug-naïve
Core Tip	Deng et al identify a TSH threshold of 5.43 μIU/mL as a significant predictor of suicide attempts in first-episode drug-naïve-major depressive disorder (MDD) patients. However, to translate these findings into clinical practice, researchers must account for the biological reality that hypothyroidism and MDD phenotypes differ significantly by sex. Additionally, the relationship between thyroid-stimulating hormone and suicide should be interpreted within the broader context of metabolic health, as thyroid function and lipid/glucose metabolism are physiologically intertwined and collectively influence neurobiological vulnerability to self-harm.
Citation	Nagamine T. Letter to the Editor: Insight into the nonlinear association between thyroid-stimulating hormone and suicide risk in first-episode major depressive disorder. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.120652
PDF	120652-in-press.pdf

Received	2026-03-05 02:14
Peer-Review Started	2026-03-05 02:18
First Decision by Editorial Office Director	2026-04-10 06:11
Return for Revision	2026-04-10 06:11
Revised	2026-04-10 07:27
Publication Fee Transferred
Second Decision by Editor	2026-07-14 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-14 07:08
Articles in Press	2026-07-14 07:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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