Publication Name	World Journal of Gastroenterology
Manuscript ID	120674
DOI	10.3748/wjg.120674
Country	China

Category	Health Care Sciences & Services
Manuscript Type	Case Report
Article Title	Tangier disease with heterozygous mutations in the ABCA1 gene: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Xiu-Fang Xu, Jie-Wei Wang, Li-Ying Wang and Chun-Xiao Chen
Funding Agency and Grant Number
Corresponding Author	Li-Ying Wang, Department of Gastroenterology, Shaoxing Shangyu People’s Hospital, No. 517 Shimin Avenue, Baiguan Subdistrict, Shangyu 312300, Zhejiang Province, China. 2847027544@qq.com
Key Words	Tangier disease; ABCA1 gene; Gastrointestinal mucosal abnormalities; Splenomegaly; High-density lipoprotein cholesterol
Core Tip	We report a rare case of Tangier disease. The final diagnosis was established based on abnormal gastrointestinal mucosal changes found on endoscopy, the patient’s medical history and family history, and gene tests. Tangier disease is a rare inherited metabolic disorder characterized by familial high-density lipoprotein deficiency. The main features of this disease include extremely low plasma high-density lipoprotein levels and cholesterol accumulation in tissue macrophages, which can involve multiple organ systems. Therefore, early recognition and diagnosis are crucial for guiding clinical management.
Citation	Xu XF, Wang JW, Wang LY, Chen CX. Tangier disease with heterozygous mutations in the ABCA1 gene: A case report. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.120674
PDF	120674-in-press.pdf

Received	2026-03-12 02:03
Peer-Review Started	2026-03-12 02:03
First Decision by Editorial Office Director	2026-04-23 09:43
Return for Revision	2026-04-23 09:43
Revised	2026-05-11 11:05
Publication Fee Transferred	2026-05-13 11:46
Second Decision by Editor	2026-06-30 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-30 07:30
Articles in Press	2026-06-30 07:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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