Publication Name	World Journal of Stem Cells
Manuscript ID	120694
DOI	10.4252/wjsc.120694
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Retrospective Study
Article Title	Very small embryonic-like stem cells: A predictor synergizing with complement and inflammatory factors for immunoglobulin A nephropathy prognosis
Manuscript Source	Unsolicited Manuscript
All Author List	Cheng-Li Lou, Ke-Xin Ren, Xiu-Qin Xu, Xiang-Jing Wang, Xiao-Ping Fan, Bo Feng, Ping-Xin Hu and Yi-Jing Zhou
Funding Agency and Grant Number	Funding Agency Grant Number Zhejiang Provincial Traditional Chinese Medicine Science and Technology Program 2026ZL0854
Corresponding Author	Yi-Jing Zhou, Chief Physician, Department of Nephrology, Jiaxing Hospital of Traditional Chinese Medicine, No. 1501 Zhongshan East Road, Jiaxing 314001, Zhejiang Province, China. zyj13967332522@163.com
Key Words	Complement alternative pathway; Stem cell indicators; Inflammatory markers; Immunoglobulin A nephropathy; Estimated glomerular filtration rate; End-stage renal disease
Core Tip	As a key stem cell indicator, very small embryonic-like stem cells, combined with complement alternative pathway indices and inflammatory biomarker tumor necrosis factor-α, are independent predictors of end-stage renal disease in immunoglobulin A nephropathy patients. Their combined detection yields high predictive accuracy, outperforming single indicators and enabling reliable risk stratification. High very small embryonic-like stem cells correlate with poor renal prognosis, and these serological markers predict outcomes independent of Oxford classification, providing a non-invasive alternative to renal biopsy and enriching individualized intervention biomarkers.
Citation	Lou CL, Ren KX, Xu XQ, Wang XJ, Fan XP, Feng B, Hu PX, Zhou YJ. Very small embryonic-like stem cells: A predictor synergizing with complement and inflammatory factors for immunoglobulin A nephropathy prognosis. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.120694
PDF	120694-in-press.pdf

Received	2026-03-27 11:12
Peer-Review Started	2026-03-27 11:12
First Decision by Editorial Office Director	2026-04-15 07:48
Return for Revision	2026-04-15 07:48
Revised	2026-05-01 15:33
Publication Fee Transferred	2026-05-12 09:02
Second Decision by Editor	2026-06-11 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-18 08:16
Articles in Press	2026-06-18 08:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com