Publication Name	World Journal of Diabetes
Manuscript ID	120721
Country	Türkiye

Category	Biochemistry & Molecular Biology
Manuscript Type	Editorial
Article Title	Targeting the CTRP3-PTEN-PI3K/AKT axis in diabetic wound repair: Implications for keratinocyte resilience
Manuscript Source	Invited Manuscript
All Author List	Hadi Karimkhani
Funding Agency and Grant Number
Corresponding Author	Hadi Karimkhani, Assistant Professor, PhD, Medical Biochemistry, Istanbul Okan University, Medical School, Tepeören Mahallesi Tuzla Kampüsü, Istanbul 34959, Türkiye. drhadi.h@gmail.com
Key Words	CTRP3; Diabetic wound healing; Keratinocytes; PTEN; PI3K/AKT signaling; Angiogenesis
Core Tip	Diabetic wound healing is severely impaired by metabolic dysregulation, chronic inflammation, and defective keratinocyte function. Emerging evidence highlights CTRP3 as a metabolically responsive adipokine with regenerative potential. Recent experimental findings indicate that CTRP3 promotes keratinocyte proliferation, migration, and angiogenic signaling while suppressing PTEN to activate the PI3K/AKT pathway. This editorial discusses how the CTRP3-PTEN-PI3K/AKT axis integrates metabolic signaling with epithelial repair processes and may represent a promising molecular target for improving diabetic wound healing outcomes.
Citation	Karimkhani H. Targeting the CTRP3-PTEN-PI3K/AKT axis in diabetic wound repair: Implications for keratinocyte resilience. World J Diabetes 2026; In press

Received	2026-03-10 00:24
Peer-Review Started	2026-03-12 01:50
First Decision by Editorial Office Director	2026-04-04 02:15
Return for Revision	2026-04-04 02:15
Revised	2026-05-10 16:05
Publication Fee Transferred
Second Decision by Editor	2026-05-28 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-28 03:10
Articles in Press	2026-05-28 03:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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