Publication Name	World Journal of Critical Care Medicine
Manuscript ID	120778
Country	United States

Category	Clinical Neurology
Manuscript Type	Meta-Analysis
Article Title	Extracorporeal membrane oxygenation associated cerebral microbleeds: A systematic review and meta analysis
Manuscript Source	Invited Manuscript
All Author List	Bahadar S Srichawla, Maria Garcia-Dominguez, Manraj Sekhon, Robert Shpiner, Paul Vespa and Manuel Buitrago Blanco
Funding Agency and Grant Number
Corresponding Author	Bahadar S Srichawla, Consultant, Department of Neurosurgery and Neurology, David Geffen School of Medicine, University of California Los Angeles, 757 Westwood Plaza, Los Angeles, CA 90095, United States. bsrichawla@mednet.ucla.edu
Key Words	Extracorporeal membrane oxygenation; Cerebral microbleed; Stroke; Infarction; Extra corporeal membrane oxygenation; Intracerebral hemorrhage
Core Tip	This meta-analysis evaluates the prevalence, underlying mechanisms, and clinical impact of cerebral microbleeds in patients undergoing extracorporeal membrane oxygenation. While extracorporeal membrane oxygenation is a life-saving intervention, the intersection of necessary systemic anticoagulation, rapid hemodynamic shifts, and circuit-induced inflammation creates a perfect storm for microvascular brain injury. Our findings highlight cerebral microbleeds as a critical, yet frequently under-recognized, neurological complication. We propose that early neuroimaging and targeted hemodynamic monitoring are essential to mitigate bleeding risks and improve long-term functional outcomes in this highly vulnerable patient population.
Citation	Srichawla BS, Garcia-Dominguez M, Sekhon M, Shpiner R, Vespa P, Blanco MB. Extracorporeal membrane oxygenation associated cerebral microbleeds: A systematic review and meta analysis. World J Crit Care Med 2026; In press

Received	2026-03-09 06:18
Peer-Review Started	2026-03-09 06:19
First Decision by Editorial Office Director	2026-03-27 10:29
Return for Revision	2026-03-27 10:29
Revised	2026-05-05 05:51
Publication Fee Transferred
Second Decision by Editor	2026-08-26 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-26 08:35
Articles in Press	2026-08-26 08:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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