Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	120785
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Synergistic value of systemic inflammatory and tumor markers in predicting pretreatment distant metastasis of gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Meng Shen, Xiao-Yu Hong, Hao-Chun Gao, Qiu-Lin Hao, Zheng-Yu Li, Zhi-Yuan Yao and Chao Gao
Funding Agency and Grant Number
Corresponding Author	Chao Gao, Department of Oncology, The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Xuzhou 221000, Jiangsu Province, China. gaochaoly@sina.com
Key Words	Gastric cancer; Distant metastasis; Inflammatory indicators; Tumor markers; Predictive model; Calibration curve
Core Tip	Early and accurate identification of distant metastasis before treatment remains a clinical challenge in gastric cancer. This study developed and internally validated a practical predictive model integrating routinely available inflammatory markers and tumor markers. By combining carbohydrate antigen 19-9, neutrophil count, lymphocyte count, and tumor location, the model demonstrated good discrimination, calibration, and clinical net benefit. The proposed model provides a convenient and cost-effective tool for pre-treatment risk stratification, which may assist clinicians in optimizing diagnostic strategies and individualized management for patients with gastric cancer.
Citation	Shen YM, Hong XY, Gao HC, Hao QL, Li ZY, Yao ZY, Gao C. Synergistic value of systemic inflammatory and tumor markers in predicting pretreatment distant metastasis of gastric cancer. World J Gastrointest Oncol 2026; In press

Received	2026-03-09 03:25
Peer-Review Started	2026-03-09 03:27
First Decision by Editorial Office Director	2026-03-20 10:07
Return for Revision	2026-03-20 10:07
Revised	2026-03-27 10:30
Publication Fee Transferred	2026-04-17 08:39
Second Decision by Editor	2026-04-16 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-16 06:45
Articles in Press	2026-04-16 06:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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