Publication Name	World Journal of Gastroenterology
Manuscript ID	120795
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Clinicopathological characteristics and survival outcomes of early-onset vs mid-aged gastric cancer using an evidence-based age cutoff
Manuscript Source	Unsolicited Manuscript
All Author List	Seong-A Jeong, Jung Bok Lee and Ji Hoon Kim
Funding Agency and Grant Number
Corresponding Author	Seong-A Jeong, MD, Division of Gastrointestinal Surgery, Department of Surgery, Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea. sajeong90@gmail.com
Key Words	Stomach neoplasms; Early-onset gastric cancer; Cohort studies; Survival analysis; Prognosis
Core Tip	This study compares early-onset gastric cancer (EOGC) and mid-aged gastric cancer (M-GC) using an evidence-based age cutoff of 50 years and inverse probability of treatment weighting to minimize age-related confounders. Despite a higher prevalence of aggressive diffuse-type histology, EOGC patients demonstrated superior recurrence-free and overall survival compared to M-GC patients. These findings suggest that the perceived biological aggressiveness of EOGC does not necessarily translate into poorer outcomes when standardized radical surgery and adjuvant therapies are effectively delivered. This underscores the importance of optimized management for the growing young adult patient population.
Citation	Jeong SA, Lee JB, Kim JH. Clinicopathological characteristics and survival outcomes of early-onset vs mid-aged gastric cancer using an evidence-based age cutoff. World J Gastroenterol 2026; In press

Received	2026-03-09 02:42
Peer-Review Started	2026-03-09 02:43
First Decision by Editorial Office Director	2026-03-13 10:28
Return for Revision	2026-03-13 10:28
Revised	2026-03-26 10:19
Publication Fee Transferred	2026-04-10 08:30
Second Decision by Editor	2026-04-10 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-10 07:32
Articles in Press	2026-04-10 07:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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