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Articles in Press
6/10/2026 7:20:23 AM | Browse: 1 | Download: 0
| Category |
Orthopedics |
| Manuscript Type |
Evidence Review |
| Article Title |
Intervertebral disc degeneration and aging: Shared molecular mechanisms and therapeutic interventions
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Peng Wang, Hong-Wei Zhang, Xi-Yun Zhao, Yuan-Zhen Li, Xiao-Gang Zhang, Rui Zhao and Da-Ping Qin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation Project |
No. 82505367 |
| Gansu Provincial Youth Talent Individual Project |
No. 2025QNGR72 |
| Natural Science Foundation of Gansu Province |
No. 24JRRA1037 |
| The Longyuan Talent Program of the Organization Department of the Communist Party of Gansu Province (Issued by the Provincial Party Committee Talent Team |
No. 11 |
| Youth Science and Technology Program of Lanzhou Bureau of Science and Technology |
No. 2023-2-47 and No. 2023-2-48 |
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| Corresponding Author |
Hong-Wei Zhang, PhD, Department of Orthopedics, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, No. 732, Jiayuguan West Road, Chengguan District, Lanzhou City, Lanzhou 730020, Gansu Province, China. 961409730@qq.com |
| Key Words |
Intervertebral disc degeneration; Aging; Oxidative stress; Cellular senescence |
| Core Tip |
This review highlights the shared molecular mechanisms between intervertebral disc degeneration and aging, such as extracellular matrix degradation, apoptosis, inflammation, and oxidative stress. It explores their bidirectional relationship and discusses multi-target pharmacological interventions that show promise in slowing degeneration with favorable safety. The insights provide a theoretical basis for early intervention and precision treatment. |
| Citation |
Wang ZP, Zhang HW, Zhao XY, Li YZ, Zhang XG, Zhao R, Qin DP. Intervertebral disc degeneration and aging: Shared molecular mechanisms and therapeutic interventions. World J Orthop 2026; In press
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| PDF |
120800-in-press.pdf
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Received |
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2026-03-12 01:28 |
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Peer-Review Started |
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2026-03-12 01:28 |
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First Decision by Editorial Office Director |
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2026-03-26 10:24 |
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Return for Revision |
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2026-03-26 10:24 |
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Revised |
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2026-04-19 11:49 |
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Publication Fee Transferred |
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2026-04-26 15:18 |
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Second Decision by Editor |
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2026-06-10 02:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-10 07:20 |
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Articles in Press |
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2026-06-10 07:20 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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