Publication Name	World Journal of Clinical Cases
Manuscript ID	120825
Country	China

Category	Dermatology
Manuscript Type	Case Report
Article Title	Kaposi sarcoma following dupilumab treatment for bullous pemphigoid: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Sheng-Nan Wang, Jin-Meng Wang, Mian Xu and Jing-Jing Wu
Funding Agency and Grant Number
Corresponding Author	Jing-Jing Wu, MD, Department of Dermatology, Wenzhou Central Hospital, No.252 Baili East Road, Lucheng District, Wenzhou 325000, Zhejiang Province, China. 359680756@qq.com
Key Words	Bullous pemphigoid; Dupilumab; Kaposi’s sarcoma; Interleukin-6/TYK2/STAT3; Kaposi sarcoma-associated herpesvirus; Herpesvirus 8; Immune evasion; Case report
Core Tip	Dupilumab was used to treat bullous pemphigoid (BP) complicated with Kaposi sarcoma (KS). The causes were analyzed, and the immune drift induction hypothesis was proposed. STAT3 plays a key role in KS pathogenesis, as it supports human herpesvirus-8 latency and viral replication. It can be activated by virally encoded interleukin-6 via gp130 receptor signaling to promote the survival and proliferation of infected cells. Dupilumab-induced immune deviation (toward Th1/Th17/Th22 pathways) and STAT3 signaling activation may contribute to KS occurrence in susceptible BP patients. Further investigation is needed.
Citation	Wang SN, Wang JM, Mian Xu M, Wu JJ. Kaposi sarcoma following dupilumab treatment for bullous pemphigoid: A case report and review of literature. World J Clin Cases 2026; In press

Received	2026-03-12 01:45
Peer-Review Started	2026-03-12 01:49
First Decision by Editorial Office Director	2026-03-20 10:42
Return for Revision	2026-03-20 10:42
Revised	2026-04-01 09:02
Publication Fee Transferred
Second Decision by Editor	2026-04-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-22 06:13
Articles in Press	2026-04-22 06:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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