Publication Name	World Journal of Stem Cells
Manuscript ID	120831
DOI	10.4252/wjsc.120831
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Mesenchymal stem cells therapy ameliorates esophageal dysmotility in gastroesophageal reflux disease by modulating smooth muscle contractility, alleviating senescence by targeting the DNMT3a-HIF1α axis
Manuscript Source	Unsolicited Manuscript
All Author List	Yi Li, Wen-Ya Zhu, Bo Zhang, Ze-Rui Wang, Zhao-Yang Chen, Qian-Qian Chen and En-Qiang Linghu
Funding Agency and Grant Number	Funding Agency Grant Number China Postdoctoral Science Foundation 2020TQ0131 Natural Science Foundation of Beijing Municipality 7232151
Corresponding Author	En-Qiang Linghu, Department of Gastroenterology, The First Medical Center, General Hospital of the Chinese PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. linghuenqiang@vip.sina.com
Key Words	Mesenchymal stem cells; Gastroesophageal reflux disease; Esophageal dysmotility; DNA methyltransferase 3a/hypoxia-inducible factor 1 alpha axis
Core Tip	This work shows mesenchymal stem cells (MSCs) restore impaired esophageal contractility and reduce inflammation in gastroesophageal reflux disease by regulating ion channels and smooth muscle proteins. MSCs counteract tumor necrosis factor-α-accelerated cell senescence and dysfunction, with DNA methyltransferase 3a and hypoxia-inducible factor 1 alpha pathways implicated. These results uncover critical mechanisms for MSC-mediated regenerative effects, proposing a promising cell-based therapeutic approach for restoring physiological function in gastroesophageal reflux disease.
Citation	Li Y, Zhu WY, Zhang B, Wang ZR, Chen ZY, Chen QQ, Linghu EQ. Mesenchymal stem cells therapy ameliorates esophageal dysmotility in gastroesophageal reflux disease by modulating smooth muscle contractility, alleviating senescence by targeting the DNMT3a-HIF1α axis. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.120831

Received	2026-03-13 01:49
Peer-Review Started	2026-03-13 01:49
First Decision by Editorial Office Director	2026-03-26 10:15
Return for Revision	2026-03-26 10:15
Revised	2026-04-07 11:05
Publication Fee Transferred	2026-04-13 11:43
Second Decision by Editor	2026-05-25 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-03 09:37
Articles in Press	2026-06-03 09:37
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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