Publication Name	World Journal of Critical Care Medicine
Manuscript ID	120840
Country	Brazil

Category	Critical Care Medicine
Manuscript Type	Minireviews
Article Title	Hemophagocytic lymphohistiocytosis in critically ill patients: A guide for clinicians
Manuscript Source	Invited Manuscript
All Author List	Wagner Nedel
Funding Agency and Grant Number
Corresponding Author	Wagner Nedel, Assistant Professor, MD, PhD, Department of Intensive Care Unit, Conceição Hospital Group, Francisco Trein 596, Segundo Andar, Porto Alegre 91350200, Brazil. wagnernedel@gmail.com
Key Words	Hemophagocytic lymphohistiocytosis; Macrophage-activation syndrome; Sepsis with hepatobiliary dysfunction and disseminated intravascular coagulation; Immune response; Multiorgan failure
Core Tip	Secondary hemophagocytic lymphohistiocytosis is a severe hyperinflammatory condition that frequently resembles or complicates sepsis in patients who are critically ill. A high level of clinical suspicion is necessary when patients present with ongoing fever, unexplained reductions in blood cell counts, and extremely high levels of ferritin. Employing the HScore or hemophagocytic lymphohistiocytosis-2004 criteria aids in making an earlier diagnosis. Swift, multidisciplinary management that emphasizes identifying triggers and applying customized immunosuppression is crucial to lowering the high mortality rates linked to multiorgan failure.
Citation	Nedel W. Hemophagocytic lymphohistiocytosis in critically ill patients: A guide for clinicians. World J Crit Care Med 2026; In press

Received	2026-03-10 01:33
Peer-Review Started	2026-03-10 01:33
First Decision by Editorial Office Director	2026-03-27 10:29
Return for Revision	2026-03-27 10:29
Revised	2026-04-12 14:35
Publication Fee Transferred
Second Decision by Editor	2026-06-01 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-01 08:56
Articles in Press	2026-06-01 08:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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