Publication Name	World Journal of Transplantation
Manuscript ID	120865
Country	Greece

Category	Surgery
Manuscript Type	Review
Article Title	Preconditioning with sufentanil confers protective effects in transplantation by attenuating hepatic ischemia-reperfusion injury
Manuscript Source	Invited Manuscript
All Author List	Christina Mouratidou, Efstathios T Pavlidis, Georgios Katsanos, Athanasios Kofinas, Alexandra G Marneri, Kalliopi E Stavrati, Georgios Tsoulfas and Theodoros E Pavlidis
Funding Agency and Grant Number
Corresponding Author	Theodoros E Pavlidis, MD, PhD, Professor Emeritus, The Second Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki 54642, Greece. pavlidth@auth.gr
Key Words	Hepatic ischemia-reperfusion injury; Liver transplantation; Ferroptosis; Iron metabolism; Lipid peroxidation; Oxidative stress; Hepatocellular injury; Sufentanil
Core Tip	Ferroptosis is critically involved in the pathogenesis of hepatic ischemia-reperfusion injury, primarily through the coordinated disruption of iron homeostasis, lipid peroxidation processes, and antioxidant defense mechanisms. Ferroptosis is characterized by morphological and biochemical features that differentiate it from apoptosis and necrosis; the inhibition of ferroptosis results in the reduction of injury markers, improving liver function in an experimental setting. Beyond its established analgesic properties, sufentanil may confer hepatoprotective effects by modulating pathways associated with ferroptosis. Investigating the interplay between sufentanil and ferroptotic mechanisms could yield valuable therapeutic strategies that enhance clinical outcomes in liver surgery and transplantation.
Citation	Mouratidou C, Pavlidis ET, Katsanos G, Kofinas A, Marneri AG, Stavrati KE, Tsoulfas G, Pavlidis TE. Preconditioning with sufentanil confers protective effects in transplantation by attenuating hepatic ischemia-reperfusion injury. World J Transplant 2026; In press

Received	2026-03-10 01:20
Peer-Review Started	2026-03-10 01:32
First Decision by Editorial Office Director	2026-03-27 10:56
Return for Revision	2026-03-27 10:56
Revised	2026-03-30 20:45
Publication Fee Transferred
Second Decision by Editor	2026-04-09 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-09 09:05
Articles in Press	2026-04-09 09:05
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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