Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	120868
DOI	10.5409/wjcp.120868
Country	India

Category	Ophthalmology
Manuscript Type	Retrospective Study
Article Title	Autologous in vitreo generated plasmin assisted vitrectomy in the pediatric population
Manuscript Source	Invited Manuscript
All Author List	Prema Subramaniam, Ninan Jacob, Veerappan Rathinasabapathy Saravanan, Parag K Shah, Abhishek Das and Narendran Venkatapathy
Funding Agency and Grant Number
Corresponding Author	Parag K Shah, Professor, Department of Pediatric Retina and Ocular Oncology, Postgraduate Institute of Ophthalmology, Aravind Eye Hospital, Avinashi Road, Coimbatore 641014, Tamil Nādu, India. drshahpk2002@yahoo.com
Key Words	Autologous whole blood; Enzymatic vitreolysis; Pediatric vitreo-retinal surgeries; Plasmin; Retinal detachment; Tissue plasminogen activator
Core Tip	Posterior vitreous detachment (PVD) a key to success in all vitreo-retinal surgeries is a crucial and challenging step in pediatric vitreo-retinal surgeries especially syndromic retinal detachments. Surgical success is not fruitful even in experiences hands. Use of enzymatic vitreolysis (with plasmin) is promising in PVD induction, but unfortunately it usage is restricted due to limitation in procuring these less durable enzymes. This method of in vivo plamin generation by injecting readily available agent (autologous whole blood) and tissue plasminogen activator yields plasmin inside the vitreous cavity and help in PVD induction henceforth surgical success. This Retrospective pilot study will be eye opener for practising vitreo-retinal surgeons.
Citation	Subramaniam P, Jacob N, Saravanan VR, Shah PK, Das A, Venkatapathy N. Autologous in vitreo generated plasmin assisted vitrectomy in the pediatric population. World J Clin Pediatr 2026; In press DOI: https://doi.org/10.5409/wjcp.120868
PDF	120868-in-press.pdf

Received	2026-03-11 03:21
Peer-Review Started	2026-03-11 03:22
First Decision by Editorial Office Director	2026-03-27 10:26
Return for Revision	2026-03-27 10:26
Revised	2026-04-17 04:22
Publication Fee Transferred
Second Decision by Editor	2026-06-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-22 08:47
Articles in Press	2026-06-22 08:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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