Publication Name	World Journal of Nephrology
Manuscript ID	120870
DOI	10.5527/wjn.120870
Country	Egypt

Category	Urology & Nephrology
Manuscript Type	Randomized Controlled Trial
Article Title	Lactulose vs Lactobacillus acidophilus for patients with chronic kidney disease: A randomized controlled trial
Manuscript Source	Invited Manuscript
All Author List	Alshaimaa S Mubarak, Ashraf Elshazly, Abdelrahman Mokhtar, Rabea A Gadelkareem and Nashwa M Azoz
Funding Agency and Grant Number
Corresponding Author	Rabea A Gadelkareem, Department of Urology, Assiut Urology and Nephrology Hospital, Faculty of Medicine, Assiut University, Elgamaa Street, Assiut 71515, Egypt. rabeagad@aun.edu.eg
Key Words	Chronic kidney disease; Lactulose; Lactobacillus acidophilus; Gut microbiota; Uremic toxins; Inflammation
Core Tip	Modulation of the gut-kidney axis represents a promising adjunctive strategy in the management of chronic kidney disease (CKD). This study highlights that both lactulose and Lactobacillus acidophilus improve uremic parameters and gastrointestinal symptoms in CKD patients; however, Lactobacillus acidophilus demonstrates a more pronounced effect on reducing uremic toxin burden and systemic inflammation. These findings support the clinical relevance of targeting gut dysbiosis to slow disease progression and improve patient outcomes in CKD.
Citation	Mubarak AS, Elshazly A, Mokhtar A, Gadelkareem RA, Azoz NM. Lactulose vs Lactobacillus acidophilus for patients with chronic kidney disease: A randomized controlled trial. World J Nephrol 2026; In press DOI: https://doi.org/10.5527/wjn.120870
PDF	120870-in-press.pdf

Received	2026-03-10 01:51
Peer-Review Started	2026-03-10 01:51
First Decision by Editorial Office Director	2026-05-18 06:55
Return for Revision	2026-05-18 06:55
Revised	2026-05-31 12:16
Publication Fee Transferred
Second Decision by Editor	2026-06-29 02:21
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-29 05:11
Articles in Press	2026-06-29 05:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com