Publication Name	World Journal of Gastroenterology
Manuscript ID	120873
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	N6-methyladenosine RNA methylation in relation to the inflammatory response, immunity and the intestinal microbiota in inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Lie Zheng and Sheng-Lei Duan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82574996 Shaanxi Province Traditional Chinese Medicine Research and Innovation Talent Plan Project No. TZKN-CXRC-16 Project of Shaanxi Administration of Traditional Chinese Medicine No. SZY-KJCYC-2025-JC-010 Shaanxi Province Key Research and Development Plan Project-Social Development Field No. 2025SF-YBXM-498 The “Nursery Cultivation Plan” project of Shaanxi Provincial Academy of Chinese Medicine and Shaanxi Provincial Hospital of Traditional Chinese Medicine for the year 2025 No. 2025-04 The Fifth Batch of Outstanding Clinical Talents in Traditional Chinese Medicine Project of Shaanxi Province, Shaanxi Traditional Chinese Medicine Letter [2025] No. 6
Corresponding Author	Sheng-Lei Duan, Department of Gastroenterology, Shaanxi Hospital of Traditional Chinese Medicine, No. 4 Xihuamen, Xi’an 710003, Shaanxi Province, China. 281930369@qq.com
Key Words	N6-methyladenosine; RNA methylation; Immunity; Intestinal microbiota; Inflammatory bowel disease
Core Tip	Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine. N6-methyladenosine (m6A) RNA methylation, which is the most abundant messenger RNA modification in mammalian cells, plays an important role in IBD by influencing various processes, such as RNA stability, splicing, translation, and degradation, and participating in the pathogenesis of IBD. The key enzymes involved in m6A methylation (such as methyltransferase-like 3, methyltransferase-like 4 and fat mass and obesity-associated protein) not only regulate changes in inflammation and immunity in IBD but also bidirectionally regulate the intestinal microenvironment. However, the specific mechanism of m6A methylation modification in IBD needs further exploration. Future research should focus on clarifying the molecular network related to m6A methylation and IBD to provide new intervention methods for clinical practice and improve the outcomes of IBD patients. This article reviews the research progress on m6A RNA methylation in IBD, aiming to improve the understanding of IBD pathogenesis at the epigenetic level and provide new directions for exploring treatments targeting m6A-modified related proteins for IBD.
Citation	Zheng L, Duan SL. N6-methyladenosine RNA methylation in relation to the inflammatory response, immunity and the intestinal microbiota in inflammatory bowel disease. World J Gastroenterol 2026; In press

Received	2026-03-11 03:36
Peer-Review Started	2026-03-11 03:36
First Decision by Editorial Office Director	2026-03-20 11:42
Return for Revision	2026-03-20 11:42
Revised	2026-04-11 00:14
Publication Fee Transferred
Second Decision by Editor	2026-05-07 03:22
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-07 06:24
Articles in Press	2026-05-07 06:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com