Publication Name	World Journal of Psychiatry
Manuscript ID	120880
DOI	10.5498/wjp.120880
Country	China

Category	Psychiatry
Manuscript Type	Case Report
Article Title	Olanzapine-induced restless legs syndrome: Two case reports
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Liang Li
Funding Agency and Grant Number
Corresponding Author	Hong-Liang Li, Academic Fellow, Lecturer, Department of Clinic, Jurong Mental Hospital, No. S243 Hongjing Road, Jurong City, Zhenjiang 212400, Jiangsu Province, China. 291413125@qq.com
Key Words	Olanzapine; Restless legs syndrome; Schizophrenia; Adverse drug reaction; Case report
Core Tip	Olanzapine-induced restless legs syndrome (RLS) is a rare adverse drug reaction with an incidence of only 0.5%-2.3%, easily ignored in psychiatric practice. This article reports two elderly female schizophrenia patients complicated with multiple physical illnesses who developed typical RLS after olanzapine administration. We analyze its possible mechanisms related to dopaminergic dysfunction and abnormal iron metabolism, summarize individualized dose adjustment and antipsychotic switching strategies, and remind clinicians to actively screen RLS symptoms during olanzapine treatment.
Citation	Li HL. Olanzapine-induced restless legs syndrome: Two case reports. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.120880

Received	2026-03-11 03:06
Peer-Review Started	2026-03-11 03:07
First Decision by Editorial Office Director	2026-06-02 08:40
Return for Revision	2026-06-02 08:40
Revised	2026-06-10 15:43
Publication Fee Transferred	2026-06-16 08:39
Second Decision by Editor	2026-07-06 08:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-06 08:47
Articles in Press	2026-07-06 08:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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