Publication Name	World Journal of Gastroenterology
Manuscript ID	120885
DOI	10.3748/wjg.120885
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Portulaca oleracea L.-derived exosome-like nanoparticles ameliorate colitis by modulating gut microbiota and metabolites to reduce endoplasmic reticulum stress
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Yan Liu, Zi-Xuan Liu, Wei-Wei Tan, Wei-Bing Zhang, Dan Qiao, Shuo-Han Chen, Ya-Li Zhang, Lie Zheng, Wen-Song Ge and Yan-Cheng Dai
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81873253 National Natural Science Foundation of China 82574996 Shanghai Natural Science Foundation 22ZR1458800 Scientific Research Project Plan of Shanghai Municipal Health Commission 202240385 Hongkou District Health Committee HKZK2020A01 Shaanxi Province Traditional Chinese Medicine Research and Innovation Talent Plan Project TZKN-CXRC-16 Project of Shaanxi Administration of Traditional Chinese Medicine SZY-KJCYC-2025-JC-010 Shaanxi Province Key Research and Development Plan Project-Social Development Field 2025SF-YBXM-498
Corresponding Author	Yan-Cheng Dai, PhD, Department of Gastroenterology, Shanghai Traditional Chinese Medicine-Integrated Hospital Shanghai University of Traditional Chinese Medicine, No. 230 Baoding Road, Hongkou District, Shanghai 200082, China. daiyancheng2005@126.com
Key Words	Portulaca oleracea L.-derived exosome-like nanoparticles; Ulcerative colitis; Endoplasmic reticulum stress; Tight junction; PERK-eIF2α-ATF4 signaling pathway; Gut microbiota; Metabolites
Core Tip	The role of Portulaca oleracea L. (P. oleracea L.) in modulating endoplasmic reticulum stress, gut microbiota and metabolites remained unclear. To investigate this, we prepared exosome-like nanoparticles derived from P. oleracea L. and modeled colitis induced by dextran sulfate sodium and microbiota-transplanted mouse. We found that P. oleracea L.-derived exosome-like nanoparticles (PELNs) intervention alleviated colitis through the modulation of the intestinal microbial community and metabolites. PELNs as a novel, food-derived, colon-targeted therapeutic, offering a promising approach for ulcerative colitis treatment.
Citation	Liu XY, Liu ZX, Tan WW, Zhang WB, Qiao D, Chen SH, Zhang YL, Zheng L, Ge WS, Dai YC. Portulaca oleracea L.-derived exosome-like nanoparticles ameliorate colitis by modulating gut microbiota and metabolites to reduce endoplasmic reticulum stress. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.120885
PDF	120885-in-press.pdf

Received	2026-03-11 03:02
Peer-Review Started	2026-03-11 03:03
First Decision by Editorial Office Director	2026-04-22 10:40
Return for Revision	2026-04-22 10:40
Revised	2026-05-03 13:00
Publication Fee Transferred	2026-05-08 07:48
Second Decision by Editor	2026-06-23 02:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-23 05:33
Articles in Press	2026-06-23 05:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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