Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	120904
DOI	10.4251/wjgo.120904
Country	China

Category	Oncology
Manuscript Type	Meta-Analysis
Article Title	High-dose vs standard radiotherapy in rectal cancer: Effects on tumour response, toxicity, and organ preservation
Manuscript Source	Unsolicited Manuscript
All Author List	Ting Long, Han Gao, Wan-Qi He, Wei-Wei Xiao and Xi-Cheng Wang
Funding Agency and Grant Number
Corresponding Author	Xi-Cheng Wang, Professor, Department of Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical University, No. 19 Nonglinxia Road, Yuexiu District, Guangzhou 510080, Guangdong Province, China. 13902400598@126.com
Key Words	Rectal cancer; High-dose radiotherapy; Organ preservation; Clinical complete response; Tumour regression; Toxicity; Meta-analysis
Core Tip	Radiotherapy dose escalation has been investigated as a potential approach to improve tumour response in rectal cancer. In this meta-analysis of randomized controlled trials, high-dose radiotherapy (> 54 Gy) increased clinical complete response and the proportion of patients achieving tumour regression grade 1-2 compared with standard-dose radiotherapy. Importantly, dose escalation did not significantly increase severe toxicity. These findings suggest that radiotherapy dose intensification may enhance tumour response and provide supportive evidence for organ preservation strategies in selected patients with stage I-III rectal cancer.
Citation	Long T, Gao H, He WQ, Xiao WW, Wang XC. High-dose vs standard radiotherapy in rectal cancer: Effects on tumour response, toxicity, and organ preservation. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.120904

Received	2026-03-11 02:01
Peer-Review Started	2026-03-11 02:01
First Decision by Editorial Office Director	2026-03-26 09:41
Return for Revision	2026-03-26 09:41
Revised	2026-04-08 06:03
Publication Fee Transferred
Second Decision by Editor	2026-06-02 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-02 08:55
Articles in Press	2026-06-02 08:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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