Publication Name	World Journal of Critical Care Medicine
Manuscript ID	120909
Country	Croatia

Category	Critical Care Medicine
Manuscript Type	Case Report
Article Title	Acute intermittent porphyria presenting with rhabdomyolysis and polyneuropathy with severe quadriparesis and respiratory failure: A case report
Manuscript Source	Invited Manuscript
All Author List	Luka Bielen, Ana Vujaklija Brajković, Ozrenka Zlopaša, Nediljko Šućur, Mila Lovrić, Anja Šitum and Penelope Stein
Funding Agency and Grant Number
Corresponding Author	Ana Vujaklija Brajković, Assistant Professor, MD, PhD, Department of Internal Medicine, University Hospital Centre Zagreb, Kišpatićeva 12, Zagreb 10000, Croatia. avujaklija@gmail.com
Key Words	Acute intermittent porphyria; Rhabdomyolysis; Polyneuropathy; Hemin; Givosiran; Case report
Core Tip	Rhabdomyolysis is a rare but important manifestation of an acute intermittent porphyria (AIP) attack. In this clinical scenario, urine discolouration might erroneously be ascribed to rhabdomyolysis, underlying the need for AIP diagnostic workup in the right clinical context. Our case illustrates that treatment with hemin and givosiran for longer than two years may be needed after a severe AIP attack with rhabdomyolysis and severe quadriparesis. If the period between givosiran administrations is prolonged, the physician must be vigilant for the possibility of a new attack.
Citation	Bielen L, Vujaklija Brajković A, Zlopaša O, Šućur N, Lovrić M, Šitum A, Stein P. Acute intermittent porphyria presenting with rhabdomyolysis and polyneuropathy with severe quadriparesis and respiratory failure: A case report. World J Crit Care Med 2026; In press

Received	2026-03-11 03:14
Peer-Review Started	2026-03-11 03:15
First Decision by Editorial Office Director	2026-04-13 09:15
Return for Revision	2026-04-13 09:15
Revised	2026-05-04 19:06
Publication Fee Transferred
Second Decision by Editor	2026-05-21 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-21 06:57
Articles in Press	2026-05-21 06:57
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com