Publication Name	World Journal of Transplantation
Manuscript ID	120922
DOI	10.5500/wjt.120922
Country	India

Category	Ophthalmology
Manuscript Type	Minireviews
Article Title	Therapeutic penetrating keratoplasty for recalcitrant microbial keratitis: An update
Manuscript Source	Invited Manuscript
All Author List	Ujjwal P Jha, Md A Alam, Prateek Nishant, Swati Kumari, Bharat Gurnani, Kirandeep Kaur, Ranjeet K Sinha and Sony Sinha
Funding Agency and Grant Number
Corresponding Author	Sony Sinha, Department of Ophthalmology - Vitreoretina and Oculoplasty, All India Institute of Medical Sciences Patna, Patna-Aurangabad Highway, Phulwarisharif, Patna 801507, Bihār, India. dr.sony11776@aiimspatna.org
Key Words	Keratitis; Penetrating keratoplasty; Eye infections; Corneal ulcer; Surgical wound infection
Core Tip	Therapeutic penetrating keratoplasty is a surgical procedure wherein diseased infected host corneal tissue is replaced by a full-thickness donor cornea for eliminating infection and maintaining globe integrity. However, recurrence of infection in the graft remains a concern, especially in cases of resistant organisms such as Acanthamoeba, Pythium, or microsporidia or even in cases of some bacterial and fungal keratitis. The purpose of this review is to provide a comprehensive review and an update of peer-reviewed literature published over the last decade with emphasis on recalcitrant infections due to these pathogens.
Citation	Jha UP, Alam MA, Nishant P, Kumari S, Gurnani B, Kaur K, Sinha RK, Sinha S. Therapeutic penetrating keratoplasty for recalcitrant microbial keratitis: An update. World J Transplant 2026; In press DOI: https://doi.org/10.5500/wjt.120922
PDF	120922-in-press.pdf

Received	2026-03-12 03:32
Peer-Review Started	2026-03-12 03:32
First Decision by Editorial Office Director	2026-04-22 10:54
Return for Revision	2026-04-22 10:54
Revised	2026-05-08 18:57
Publication Fee Transferred
Second Decision by Editor	2026-06-15 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-15 09:08
Articles in Press	2026-06-15 09:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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