Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	120925
Country	United Arab Emirates

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Recurrent acute liver failure in infancy - a novel SCYL1 mutation: A case report
Manuscript Source	Invited Manuscript
All Author List	Doaa Zourob, Amal Al Teneiji, Mohammad Miqdady and Eman Al Atrash
Funding Agency and Grant Number
Corresponding Author	Eman Al Atrash, Consultant, MD, Department of Pediatrics, Division of Pediatric Gastroenterology, Mediclinic Airport Road Hospital, -, Abu Dhabi 971, United Arab Emirates. emanalatrash8@gmail.com
Key Words	SCYL1 mutation; Recurrent acute liver failure; Pediatric acute liver failure; Cholestasis, acute liver failure, and neurodegeneration syndrome; Spinocerebellar ataxia, autosomal recessive type 21; Hepatocerebellar syndrome; Neurodegeneration
Core Tip	Recurrent acute liver failure (RALF) in children is an uncommon but life- threatening condition that may mask underlying genetic disorders. We report a child with febrile RALF and subtle neurological findings in whom whole exome sequencing identified a homozygous SCYL1 mutation consistent with a hepatocerebellar syndrome. This case highlights the importance of early genetic evaluation in unexplained RALF, particularly when neurological features are present. Prompt recognition of SCYL1- related disease can refine diagnosis, guide management, prevent unnecessary investigations, and improve long-term clinical outcomes.
Citation	Zourob D, Teneiji AA, Miqdady M, Al Atrash E. Recurrent acute liver failure in infancy - a novel SCYL1 mutation: A case report. World J Clin Pediatr 2026; In press

Received	2026-03-13 02:41
Peer-Review Started	2026-03-13 02:41
First Decision by Editorial Office Director	2026-04-02 08:58
Return for Revision	2026-04-02 08:58
Revised	2026-04-16 18:43
Publication Fee Transferred
Second Decision by Editor	2026-05-25 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-25 08:31
Articles in Press	2026-05-25 08:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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