Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	120927
Country	Russia

Category	Pediatrics
Manuscript Type	Case Report
Article Title	Genetic predisposition of Asparaginase-induced hypertriglyceridemia in children with acute lymphoblastic leukemia: A case report and review of literature
Manuscript Source	Invited Manuscript
All Author List	Maria Krivosheina, Victoria Bakaleiko, Yulia Toshina, George Baratashvili, Polina Sokolnikova, Olga V Kalinina, Asiiat Alieva, Yulia Dinikina and Anna A Kostareva
Funding Agency and Grant Number	Funding Agency Grant Number the Ministry of Science and Higher Education of the Russian Federation No. 075-15-2022-301
Corresponding Author	Anna A Kostareva, Institute of Molecular Biology and Genetics, Department of Molecular Medicine and Cellular Biology, Institution of Medical Education,, Almazov National Medical Research Centre, Akkuratova Street, 2, Saint-Petersburg 197341, Russia. anna.kostareva@ki.se
Key Words	Children; Acute leukemia; Asparaginase; Toxicity; Hypertriglyceridemia; Genetics; Clinical testing; Case report
Core Tip	Pegylated (PEG) asparaginase (ASP) is a key chemotherapy agent used in pediatric acute lymphoblastic leukemia treatment protocols. This modified form of ASP exhibits prolonged activity and reduced immunogenicity, contributing to its therapeutic efficacy and dosing convenience. However, PEG-ASP therapy can lead to various toxicities, including hypertriglyceridemia (HTG). Several genes involved in triglyceride (TG) metabolism are known to influence susceptibility to this condition, with genetic variants potentially predisposing individuals to elevated TG levels. Based on the two cases presented here, we hypothesize that genetic factors may contribute to HTG in certain pediatric patients receiving PEG-ASP therapy.
Citation	Krivosheina M, Bakaleiko V, Toshina Y, Baratashvili G, Sokolnikova P, Kalinina OV, Alieva A, Dinikina Y, Kostareva AA. Genetic predisposition of Asparaginase-induced hypertriglyceridemia in children with acute lymphoblastic leukemia: Two case reports and review of literature. World J Clin Pediatr 2026; In press

Received	2026-03-19 03:56
Peer-Review Started	2026-03-19 05:50
First Decision by Editorial Office Director	2026-04-04 02:39
Return for Revision	2026-04-04 02:39
Revised	2026-04-25 20:56
Publication Fee Transferred
Second Decision by Editor	2026-05-18 02:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-18 05:32
Articles in Press	2026-05-18 05:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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