Publication Name	World Journal of Cardiology
Manuscript ID	120930
DOI	10.4330/wjc.120930
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Meta-Analysis
Article Title	Potential role of angiotensin-converting enzyme inhibitors vs beta-blockers in preventing anticancer agents-induced cardiotoxicity: A systematic review and meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Rohab Sohail, Ridda Khattak, Haider Hussain Shah, Zaraq Khan, Azeem Khan, Shahryar Chaudhry, Simran Patel, Rohan Patel, Vyom Patel, Madihah Alam, Samar Mehdi and Manjeet Singh
Funding Agency and Grant Number
Corresponding Author	Rohab Sohail, Department of Internal Medicine, Bayhealth Medical Center, 640 South State Street, Dover, DE 19904, United States. rohabsohail98@gmail.com
Key Words	Cardiotoxicity; Angiotensin converting enzyme inhibitors; Beta blockers; Anthracycline-induced cardiotoxicity; Transtuzumab-induced cardiotoxicity
Core Tip	This meta-analysis compared angiotensin-converting enzyme inhibitors (ACEI) and beta-blockers for the prevention of anti-cancer agents-induced cardiotoxicity. Across randomized controlled trials, both drug classes showed similar effectiveness in preserving left ventricular ejection fraction and preventing overall, early, and late cardiotoxicity. Overall adverse event rates were similar between groups; however, hypotension and dizziness occurred more frequently with ACEI therapy. These findings suggest that ACEI and beta-blockers provide comparable cardioprotective benefit. Choice of therapy should therefore be individualized based on patient characteristics, blood pressure profile, and tolerability. Larger, adequately powered trials with longer follow-up are needed to determine whether meaningful differences between these strategies emerge over time.
Citation	Sohail R, Khattak R, Hussain Shah H, Khan Z, Khan A, Chaudhry S, Patel S, Patel R, Patel V, Alam M, Mehdi S, Singh M. Potential role of angiotensin-converting enzyme inhibitors vs beta-blockers in preventing anticancer agents-induced cardiotoxicity: A systematic review and meta-analysis. World J Cardiol 2026; In press DOI: https://doi.org/10.4330/wjc.120930

Received	2026-03-12 00:36
Peer-Review Started	2026-03-12 01:51
First Decision by Editorial Office Director	2026-03-27 10:18
Return for Revision	2026-03-27 10:18
Revised	2026-04-13 17:40
Publication Fee Transferred
Second Decision by Editor	2026-06-02 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-02 08:28
Articles in Press	2026-06-02 08:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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