Publication Name	World Journal of Gastroenterology
Manuscript ID	120932
DOI	10.3748/wjg.120932
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Proton pump inhibitors for gastrointestinal bleeding prevention after percutaneous coronary intervention: Comparing evidence in dual antiplatelet therapy
Manuscript Source	Unsolicited Manuscript
All Author List	Rohab Sohail, Zaraq Khan, Haider Hussain Shah, Jason Orciuolo, Dwight Fan, Rohan Patel, Ana Estrada Zamudio, Shahryar Chaudhry, Ridda Khattak and Mithil Gowda Suresh
Funding Agency and Grant Number
Corresponding Author	Rohab Sohail, Department of Internal Medicine, Bayhealth Medical Center, 640 South State Street, Dover, DE 19904, United States. rohabsohail98@gmail.com
Key Words	Dual antiplatelet therapy; Percutaneous coronary intervention; Proton pump inhibitors; Gastrointestinal bleeding; All-cause mortality
Core Tip	Proton pump inhibitor (PPI) co-therapy remains an effective strategy for preventing upper gastrointestinal (GI) bleeding in patients receiving dual antiplatelet therapy after percutaneous coronary intervention. This systematic review and meta-analysis separately evaluated randomized trials and observational studies, demonstrating consistent protection against upper GI bleeding while highlighting differences in effect estimates across study designs. Observational findings regarding lower GI bleeding, major bleeding, and all-cause mortality should be interpreted cautiously because of lower certainty and potential confounding. These findings support current guideline recommendations for PPI use while emphasizing the need for further high-quality studies to clarify long-term safety and comparative efficacy among individual PPIs.
Citation	Sohail R, Khan Z, Hussain Shah H, Orciuolo J, Fan D, Patel R, Estrada Zamudio A, Chaudhry S, Khattak R, Suresh MG. Proton pump inhibitors for gastrointestinal bleeding prevention after percutaneous coronary intervention: Comparing evidence in dual antiplatelet therapy. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.120932
PDF	120932-in-press.pdf

Received	2026-03-12 00:35
Peer-Review Started	2026-03-12 01:55
First Decision by Editorial Office Director	2026-06-09 06:28
Return for Revision	2026-06-09 06:28
Revised	2026-07-26 21:05
Publication Fee Transferred	2026-08-21 17:15
Second Decision by Editor	2026-10-19 06:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-20 09:40
Articles in Press	2026-10-20 09:40
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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