Publication Name	World Journal of Diabetes
Manuscript ID	120935
DOI	10.4239/wjd.120935
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Electroacupuncture alleviates diabetic peripheral neuropathy: Regulates mitochondrial biogenesis and redistribution in peripheral nerve fibers
Manuscript Source	Unsolicited Manuscript
All Author List	Xuan Wang, Chong-Xi Yuan, Yun Liu, Wei-Feng Li, Meng-Jiang Lu, Tian-Cheng Xu, Zhi Yu and Bin Xu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82405567 National Natural Science Foundation of China No. 82074532 National Natural Science Foundation of China No. 82374577 National Natural Science Foundation of China No. 82305375 National Natural Science Foundation of China No. 82305376 National Natural Science Foundation of China No. 82505663 Applied Basic Research Program of Yancheng No. YCBK2025031 Jiangsu Province Young Scientific and Technological Talents Promotion Plan No. JSTJ-2025-890 Suzhou Science and Technology Innovation Project of Applied Basic Research (Medical and Health) No. SYW2024163
Corresponding Author	Bin Xu, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Road, Nanjing 210023, Jiangsu Province, China. xubin@njucm.edu.cn
Key Words	Acupuncture; Diabetic peripheral neuropathy; Type 2 diabetes; Mitochondria distribution; Mitochondria biogenesis
Core Tip	Current treatments for diabetic peripheral neuropathy (DPN) remain limited, and new therapeutic strategies are needed. This study suggests that electroacupuncture (EA) exerts protective effects in type 2 DPN rats and may be associated with silent information regulator 1 (SIRT1)/peroxisome proliferator-activated receptor-γ coactivator-1α-mediated mitochondrial biogenesis and mitochondrial redistribution, with more prominent changes observed in intraepidermal nerve fibers than in adjacent keratinocytes. Notably, inhibition of SIRT1 weakened the neural benefits of EA while having limited effects on systemic metabolic parameters, suggesting a partial dissociation between neural and metabolic effects.
Citation	Wang X, Yuan CX, Liu Y, Li WF, Lu MJ, Xu TC, Yu Z, Xu B. Electroacupuncture alleviates diabetic peripheral neuropathy: Regulates mitochondrial biogenesis and redistribution in peripheral nerve fibers. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.120935
PDF	120935-in-press.pdf

Received	2026-03-12 00:33
Peer-Review Started	2026-03-13 05:33
First Decision by Editorial Office Director	2026-04-10 08:09
Return for Revision	2026-04-10 08:09
Revised	2026-04-23 04:08
Publication Fee Transferred	2026-04-24 09:53
Second Decision by Editor	2026-06-10 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-17 07:38
Articles in Press	2026-06-17 07:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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