Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	120941
DOI	10.4251/wjgo.120941
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	miR-4770 promotes colorectal cancer progression by targeting PRKAA2 via m6A modification
Manuscript Source	Unsolicited Manuscript
All Author List	Bi-Shun Yi and Huan-Bin Lai
Funding Agency and Grant Number
Corresponding Author	Huan-Bin Lai, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Lishui University, No. 1188 Liyang Street, Yanquan Street, Liandu District, Lishui 323000, Zhejiang Province, China. lhb26030501@163.com
Key Words	Colorectal cancer; miR-4770; N6-methyladenosine methylation; METTL3; PRKAA2; Malignant progression
Core Tip	This study investigated the role of miR-4770 in colorectal cancer (CRC) and its regulation by N6-methyladenosine (m6A) modification. The results showed that miR-4770 and METTL3 were upregulated in CRC tissues and cells, whereas PRKAA2 was downregulated. METTL3 may promote the maturation of pri-miR-4770 through m6A modification, thereby increasing miR-4770 expression. Functionally, miR-4770 enhanced CRC cell viability, migration, and invasion by directly targeting PRKAA2 and modulating the AMPK/mTOR signaling pathway. These findings suggest that the METTL3/miR-4770/PRKAA2 axis may provide a potential mechanistic basis for CRC progression.
Citation	Yi BS, Lai HB. miR-4770 promotes colorectal cancer progression by targeting PRKAA2 via m6A modification. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.120941
PDF	120941-in-press.pdf

Received	2026-03-12 02:21
Peer-Review Started	2026-03-12 02:22
First Decision by Editorial Office Director	2026-04-02 07:29
Return for Revision	2026-04-02 07:29
Revised	2026-05-18 09:22
Publication Fee Transferred
Second Decision by Editor	2026-07-17 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-17 06:03
Articles in Press	2026-07-17 06:03
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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