Publication Name	World Journal of Gastroenterology
Manuscript ID	120954
DOI	10.3748/wjg.120954
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Cancer therapy-induced intestinal injury: Mechanisms, clinical manifestations, and management strategies
Manuscript Source	Unsolicited Manuscript
All Author List	Yang-Long Nan, Tuan-He Sun, Kai-Jie Ren, Tian-Hao Min, Yu-Yi Ma, Xin Xie, Xiao-Yuan Deng, Yuan-Chang Peng, Yuan-Yuan Liu, Shi-Yao Tong, Wei Wang, Cheng-Xue Dang and Hao Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Social Science Fund of China 23BRK014
Corresponding Author	Hao Zhang, MD, Department of Surgical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, No. 227 Yanta West Road, Xi’an 710061, Shaanxi Province, China. hao.zhang@mail.xjtu.edu.cn
Key Words	Cancer therapy; Chemotherapy; Radiotherapy; Intestinal injury; Oxidative stress; Gut microbiota; Inflammation
Core Tip	Cancer therapy-induced intestinal injury is a relatively common, multifaceted side effect of chemotherapy, radiotherapy, targeted therapy, immunotherapy and surgical interventions. The underlying mechanisms include oxidative stress, inflammation, apoptosis and dysbiosis of the gut microbiota; all of them contribute to the disruption of epithelial integrity and intestinal function. This minireview synthesizes current mechanistic insights and therapeutic strategies, with a particular emphasis on microbiota modulation, targeted interventions, and emerging regenerative approaches. A comprehensive understanding of these processes is crucial for developing personalized treatments to prevent or mitigate intestinal injury, improve patient quality of life, and optimize cancer therapy outcomes.
Citation	Nan YL, Sun TH, Ren KJ, Min TH, Ma YY, Xie X, Deng XY, Peng YC, Liu YY, Tong SY, Wang W, Dang CX, Zhang H. Cancer therapy-induced intestinal injury: Mechanisms, clinical manifestations, and management strategies. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.120954
PDF	120954-in-press.pdf

Received	2026-03-18 06:42
Peer-Review Started	2026-03-18 06:43
First Decision by Editorial Office Director	2026-04-03 09:37
Return for Revision	2026-04-03 09:37
Revised	2026-05-03 17:05
Publication Fee Transferred	2026-05-08 06:10
Second Decision by Editor	2026-06-29 02:21
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-29 05:40
Articles in Press	2026-06-29 05:40
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com