Publication Name	World Journal of Transplantation
Manuscript ID	120969
DOI	10.5500/wjt.120969
Country	India

Category	Transplantation
Manuscript Type	Retrospective Cohort Study
Article Title	Kidney transplant outcomes in patients with complement dysregulation
Manuscript Source	Invited Manuscript
All Author List	Manish Balwani, Amit Pasari, Pranjal Kashiv, Vishal Ramteke, Priyanka Tolani, Nishtha Manuja, Mohit Kurundwadkar, Shubham Dubey, Twinkle Pawar, Sunny Malde, Sushrut Gupta, Kapil Sejpal, Vijay Jeyachandran and Vivek B Kute
Funding Agency and Grant Number
Corresponding Author	Manish Balwani, Department of Nephrology, Saraswati Kidney Care Center, Near Jai Prakash Metro Station, Nagpur 440015, Mahārāshtra, India. balwani.manish@yahoo.com
Key Words	Atypical hemolytic uremic syndrome; Thrombotic microangiopathy; Kidney transplantation; Complement dysregulation; Anti-factor H antibody; CFHR1-CFHR3
Core Tip	Complement dysregulation is an important but underrecognized determinant of post-transplant thrombotic microangiopathy. In this retrospective cohort of 38 kidney transplant recipients with complement dysregulation, CFHR1-CFHR3 structural variants predominated, anti-factor H antibodies were frequent, and recurrence occurred in 18.4%. All recurrences developed within the first 1-3 weeks post-transplant and were confined to recipients with complement genetic abnormalities. All episodes were successfully controlled with individualized therapy. Overall patient survival was 94.7%. These findings support systematic complement evaluation, biologic risk stratification, and early targeted intervention to optimize transplant selection, reduce recurrence risk, and improve post-transplant graft outcomes in complement-mediated kidney disease.
Citation	Balwani M, Pasari A, Kashiv P, Ramteke V, Tolani P, Manuja N, Kurundwadkar M, Dubey S, Pawar T, Malde S, Gupta S, Sejpal K, Jeyachandran V, Kute VB. Kidney transplant outcomes in patients with complement dysregulation. World J Transplant 2026; In press DOI: https://doi.org/10.5500/wjt.120969

Received	2026-03-12 03:44
Peer-Review Started	2026-03-12 03:45
First Decision by Editorial Office Director	2026-04-15 09:15
Return for Revision	2026-04-15 09:15
Revised	2026-05-03 11:37
Publication Fee Transferred
Second Decision by Editor	2026-06-12 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-12 03:53
Articles in Press	2026-06-12 03:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
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