Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	120971
Country	United Kingdom

Category	Health Care Sciences & Services
Manuscript Type	Minireviews
Article Title	Antibiotic stewardship in the context of management of early onset neonatal sepsis-an evolving paradigm shift
Manuscript Source	Invited Manuscript
All Author List	Amit Kandhari, Megha Jagga and Sujoy Banerjee
Funding Agency and Grant Number
Corresponding Author	Sujoy Banerjee, Professor, Neonatal Medicine, Singleton Hospital, Sketty Lane, Swansea SA2 8QA, United Kingdom. sujoybanerjee@doctors.org.uk
Key Words	Infant; Newborn; Early-onset neonatal sepsis; Neonatal antibiotics; Antibiotic stewardship; Sepsis risk calculator; Serial physical examination; Antimicrobial resistance
Core Tip	Early onset neonatal sepsis is rare yet fear of missed serious infection continues to drive widespread empirical antibiotic use, exposing large numbers of well newborns to avoidable harm. This review synthesises contemporary evidence underpinning the paradigm shift in neonatal antibiotic stewardship, critically comparing traditional categorical guidelines with multivariate risk prediction tools and serial physical examination strategies. By integrating epidemiology, emerging United Kingdom and international data, and evolving clinical practice, it provides practical insights into how antibiotic exposure can be safely reduced without compromising outcomes, supporting more precise, family-centred, and evidence based care.
Citation	Kandhari A, Jagga M, Banerjee S. Antibiotic stewardship in the context of management of early onset neonatal sepsis-an evolving paradigm shift. World J Clin Pediatr 2026; In press

Received	2026-03-12 03:26
Peer-Review Started	2026-03-12 03:27
First Decision by Editorial Office Director	2026-04-03 05:01
Return for Revision	2026-04-03 05:01
Revised	2026-04-28 20:28
Publication Fee Transferred
Second Decision by Editor	2026-05-21 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-21 06:31
Articles in Press	2026-05-21 06:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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