Publication Name	World Journal of Gastroenterology
Manuscript ID	121007
DOI	10.3748/wjg.121007
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Androgen-induced gene 1 correlates with extracellular vesicle-associated cholesterol metabolism and hepatic metastasis of pancreatic cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yun-Zhao Luo, Qing Zhao, Fang-Fei Wang, Jin-Hao Li, Shao-Cheng Lyu, Zhe Liu, Ren Lang and Qiang He
Funding Agency and Grant Number	Funding Agency Grant Number the Clinical Research Enhancement Program of Beijing Chao-Yang Hospital CYTS2025C04 the Research Project of the China Association of Medical Education ZJWYH-2023-YIZHI-015
Corresponding Author	Qiang He, Chief Physician, PhD, Professor, Division of Hepatobiliary and Pancreaticosplenic Surgery, Department of General Surgery, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongti Nan Lu, Chaoyang District, Beijing 100020, China. heqiang349@163.com
Key Words	Androgen-induced gene 1; Pancreatic ductal adenocarcinoma; Liver metastasis; Small extracellular vesicle; Cholesterol metabolism; Immune remodeling
Core Tip	Active cholesterol metabolism is a hallmark of pancreatic cancer malignancy. Here, we show that tumor-intrinsic androgen-induced gene 1 knockdown disrupts this metabolic program, remodels the hepatic niche away from immunosuppression, and inhibits metastatic growth. Our findings position androgen-induced gene 1 at the intersection of metabolic and immune regulation, warranting further investigation.
Citation	Luo YZ, Zhao Q, Wang FF, Li JH, Lyu SC, Liu Z, Lang R, He Q. Androgen-induced gene 1 correlates with extracellular vesicle-associated cholesterol metabolism and hepatic metastasis of pancreatic cancer. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.121007
PDF	121007-in-press.pdf

Received	2026-03-17 01:30
Peer-Review Started	2026-03-17 01:31
First Decision by Editorial Office Director	2026-04-29 10:08
Return for Revision	2026-04-29 10:08
Revised	2026-05-27 12:36
Publication Fee Transferred	2026-05-28 13:57
Second Decision by Editor	2026-06-15 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-15 08:04
Articles in Press	2026-06-15 08:04
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Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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