Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	121010
DOI	10.4251/wjgo.121010
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Angelica sinensis polysaccharide attenuates constipation-associated colorectal carcinogenesis by inhibiting the NLRP3/Caspase-1/IL-1β inflammasome axis
Manuscript Source	Unsolicited Manuscript
All Author List	Xi Huang, Wu-Chao-Nan Liu and Ding-Xiang Li
Funding Agency and Grant Number	Funding Agency Grant Number the Natural Science Foundation of Hunan Province (General Program) No. 2025JJ50566
Corresponding Author	Ding-Xiang Li, School of Traditional Chinese Medicine, Hunan University of Traditional Chinese Medicine, No. 300 Xueshi Road, Xueshi Street, Yuelu District, Changsha 410208, Hunan Province, China. ldxlzy@hotmail.com
Key Words	Angelica sinensis polysaccharide; Constipation; Colorectal cancer; NOD-like receptor protein 3 inflammasome; Caspase-1; Interleukin-1β; Chronic inflammation; NCM460 cells; Deoxycholic acid
Core Tip	Chronic constipation has lately been considered a possible risk factor for colorectal cancer due to prolonged colonic transit time and retention of secondary bile acids, e. g., deoxycholic acid, which can lead to persistent epithelial inflammation. Here, we present that a bioactive component of the traditional Chinese medicine Yang-Gui [Angelica sinensis polysaccharide (ASP)] can effectively suppress deoxycholic acid-induced inflammatory processes in human colonic epithelial cells. Mechanistically, ASP is able to inhibit activation of the NOD-like receptor protein 3 inflammasome and its downstream cascades caspase-1/interleukin-1β signaling pathway, thereby reducing the production of several pro-inflammatory mediators in early colorectal carcinogenesis. Our findings give mechanistic support for ASP as a potential natural candidate for preventing inflammation-driven colonic carcinogenesis under chronic constipated condition.
Citation	Huang X, Liu WCN, Li DX. Angelica sinensis Polysaccharide Attenuates Constipation-Associated Colorectal Carcinogenesis by Inhibiting the NLRP3/Caspase-1/IL-1β Inflammasome Axis. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.121010
PDF	121010-in-press.pdf

Received	2026-04-24 10:58
Peer-Review Started	2026-04-24 10:58
First Decision by Editorial Office Director	2026-05-19 02:51
Return for Revision	2026-05-19 02:51
Revised	2026-06-19 10:39
Publication Fee Transferred	2026-06-24 10:38
Second Decision by Editor	2026-08-12 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-14 09:14
Articles in Press	2026-08-14 09:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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