Publication Name	World Journal of Gastroenterology
Manuscript ID	121025
DOI	10.3748/wjg.121025
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	FSCN1/ACK1 axis-dependent M2 macrophage polarization fuels colorectal cancer progression
Manuscript Source	Unsolicited Manuscript
All Author List	Zhu Wang, Chao Liu, Hao Liu, Yong Jiang and Yan Ma
Funding Agency and Grant Number
Corresponding Author	Yan Ma, Associate Chief Physician, Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Weiqi Road, Huaiyin District, Jinan 250021, Shandong Province, China. lilepingsph@163.com
Key Words	Colon cancer; Fascin actin-bundling protein-1; Activated Cdc42-associated kinase 1; Macrophage; M2 polarization
Core Tip	This study reveals that fascin actin-bundling protein-1 (FSCN1) promotes colorectal cancer progression by driving M2 macrophage polarization via activated Cdc42-associated kinase 1. FSCN1 knockdown reprograms macrophages toward an anti-tumor M1 phenotype and suppresses tumor growth, identifying the FSCN1/activated Cdc42-associated kinase 1 axis as a therapeutic target for restoring anti-tumor immunity.
Citation	Wang Z, Liu C, Liu H, Jiang Y, Ma Y. FSCN1/ACK1 axis-dependent M2 macrophage polarization fuels colorectal cancer progression. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.121025
PDF	121025-in-press.pdf

Received	2026-05-12 10:54
Peer-Review Started	2026-05-12 10:54
First Decision by Editorial Office Director	2026-05-29 08:46
Return for Revision	2026-05-29 08:46
Revised	2026-06-11 01:43
Publication Fee Transferred	2026-06-24 03:06
Second Decision by Editor	2026-07-29 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-29 10:02
Articles in Press	2026-07-29 10:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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