Publication Name	World Journal of Psychiatry
Manuscript ID	121038
Country	China

Category	Psychiatry
Manuscript Type	Prospective Study
Article Title	Real-world safety and effectiveness of lurasidone in Chinese children and adolescents with schizophrenia: Findings from a prospective cohort
Manuscript Source	Unsolicited Manuscript
All Author List	Lei Zhang, Yu-Mei Wei and Yi-Feng Shen
Funding Agency and Grant Number	Funding Agency Grant Number Collaborative Innovation Center Project of Translational Medicine, Shanghai Jiaotong University School of Medicine No. TM202116PT Clinical Research Plan of SHDC No. SHDC2022CRS032 Sumitomo Pharma (Suzhou) Co.,Ltd
Corresponding Author	Yi-Feng Shen, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Clinical Research Center for Mental Health, School of Medicine, Shanghai Jiao Tong University, No. 600 Wanping Nan Road, Shanghai 200030, China. shenyifeng@yahoo.com
Key Words	Schizophrenia; Children and adolescents; Lurasidone; Safety; Effectiveness
Core Tip	This is the first study to specifically evaluate lurasidone monotherapy in a substantial cohort of Chinese children and adolescents with schizophrenia, providing essential evidence on real-world dosing patterns, safety, and effectiveness. Pediatric patients were initiated on lurasidone at lower doses but underwent more rapid titration, ultimately reaching a slightly higher mean final and daily dose than adults. Lurasidone 40-80 mg/day was well tolerated with low rates of adverse events, suggesting potential clinical improvement, particularly in patients with more severe depressive symptoms. These findings suggest that lurasidone may be a promising treatment option for Chinese pediatric patients with schizophrenia.
Citation	Zhang L, Wei YM, Shen YF. Real-world safety and effectiveness of lurasidone in Chinese children and adolescents with schizophrenia: Findings from a prospective cohort. World J Psychiatry 2026; In press

Received	2026-03-16 03:17
Peer-Review Started	2026-03-16 03:19
First Decision by Editorial Office Director	2026-03-20 10:00
Return for Revision	2026-03-20 10:00
Revised	2026-04-16 03:24
Publication Fee Transferred	2026-04-20 06:32
Second Decision by Editor	2026-07-03 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-03 06:16
Articles in Press	2026-07-03 06:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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