Publication Name	World Journal of Gastroenterology
Manuscript ID	121041
DOI	10.3748/wjg.121041
Country	Russia

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Gut microbial metabolites as key mediators in inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Tatiana Sall, Ekaterina Litvinova, Elena Arzhanova, Stanislav Sitkin and Timur Vakhitov
Funding Agency and Grant Number	Funding Agency Grant Number Russian Science Foundation No. 20-65-47026
Corresponding Author	Stanislav Sitkin, Associate Professor, Head, MD, PhD, Senior Researcher, Functional Metabolomics and Human Microbiome Research Group, Institute of Perinatology and Pediatrics, Almazov National Medical Research Centre, Akkuratova Street, 2, St. Petersburg 197341, Russia. drsitkin@gmail.com
Key Words	Inflammatory bowel disease; Gut microbial metabolites; Butyrate; Propionate; Valerate; 2-Hydroxybutyrate; Synergistic regulatory activity; Dysbiosis; Microbe-host cross-talk; Metabiotic concept
Core Tip	Gut microbial dysbiosis is a driving factor in inflammatory bowel disease (IBD) pathogenesis, mainly through a reduced capacity of the dysbiotic microbiota to synthesize beneficial metabolites, such as short-chain fatty acids, or through increased production of pathogenic metabolites, such as hydrogen sulfide, reactive nitrogen species, and lactate. We found elevated levels of 2-hydroxybutyric acid in Muc2−/− mice’s blood and revealed its ability to worsen IBD progression in the models of the disease. Butyric, propionic, and valeric acids, especially when used in combination, had a therapeutic effect in IBD through their anti-inflammatory and immunomodulatory potential and their gut microbiota-restoring properties.
Citation	Sall T, Litvinova E, Arzhanova E, Sitkin S, Vakhitov T. Gut microbial metabolites as key mediators in inflammatory bowel disease. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.121041
PDF	121041-in-press.pdf

Received	2026-03-17 03:11
Peer-Review Started	2026-03-17 03:13
First Decision by Editorial Office Director	2026-04-03 09:27
Return for Revision	2026-04-03 09:27
Revised	2026-04-17 08:55
Publication Fee Transferred
Second Decision by Editor	2026-06-09 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-09 08:25
Articles in Press	2026-06-09 08:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com