Publication Name	World Journal of Virology
Manuscript ID	121066
DOI	10.5501/wjv.121066
Country	India

Category	Virology
Manuscript Type	Minireviews
Article Title	Junín virus and Argentine haemorrhagic fever: Virology, pathogenesis, diagnosis, and prevention strategies
Manuscript Source	Invited Manuscript
All Author List	Sita Kumari Karanam, Praveen Kumar Uppala, Naga Vishnu Kandra and Sandhya Edhi
Funding Agency and Grant Number
Corresponding Author	Praveen Kumar Uppala, Department of Pharmacology, Maharajah's College of Pharmacy, Phool Baugh, Vizianagaram 535002, Andhra Pradesh, India. praveen.chintu32@gmail.com
Key Words	Junin virus; Argentine hemorrhagic fever; Arenaviridae; Viral hemorrhagic fever; Rodent reservoirs; Candid 1 vaccine; Viral pathogenesis; Molecular diagnostics
Core Tip	Junin virus is a rodent-borne arenavirus that causes Argentine haemorrhagic fever (AHF), a serious viral disease endemic to agricultural regions of Argentina. The infection spreads mainly through contact with contaminated rodent urine, saliva, or feces, often via inhalation of aerosolized particles. AHF initially presents with fever, fatigue, muscle pain, and headache, but severe cases may progress to bleeding disorders, neurological complications, and cardiovascular instability. The disease pathogenesis involves immune system disruption, vascular injury, and coagulation abnormalities. Diagnosis depends on laboratory methods such as reverse transcription polymerase chain reaction, serological assays, and viral isolation. Early treatment with immune plasma therapy can significantly reduce mortality. Prevention strategies focus on rodent control, safe agricultural practices, public awareness, and vaccination with the Candid #1 vaccine in endemic areas.
Citation	Karanam SL, Uppala PK, Kandra NV, Edhi S. Junín virus and Argentine haemorrhagic fever: Virology, pathogenesis, diagnosis, and prevention strategies. World J Virol 2026; In press DOI: https://doi.org/10.5501/wjv.121066
PDF	121066-in-press.pdf

Received	2026-03-16 03:44
Peer-Review Started	2026-03-16 03:45
First Decision by Editorial Office Director	2026-04-16 08:17
Return for Revision	2026-04-16 08:17
Revised	2026-05-18 17:19
Publication Fee Transferred
Second Decision by Editor	2026-06-29 02:21
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-29 06:53
Articles in Press	2026-06-29 06:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3249 (online)
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