Publication Name	World Journal of Gastroenterology
Manuscript ID	121071
DOI	10.3748/wjg.121071
Country	France

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Intestinal epithelium impairment in cystic fibrosis: What consequences in clinical practice?
Manuscript Source	Unsolicited Manuscript
All Author List	Caroline Carle, Marie Mittaine, Léa Roditis, Nolwenn Laborde, Frederick Barreau and Emmanuel Mas
Funding Agency and Grant Number
Corresponding Author	Emmanuel Mas, Head, Professor, Université de Toulouse, Service de Gastroentérologie, Hépatologie, Nutrition et Maladies Héréditaires du Métabolisme, CHU Toulouse, 330 avenue de Grande Bretagne, TSA 70034, Toulouse 31059, Occitanie, France. mas.e@chu-toulouse.fr
Key Words	Cystic fibrosis; Intestinal permeability; Microbiota; Mucus layer; Intestinal stem cells
Core Tip	Several reviews in the literature consider the role of and impact on the intestines in cystic fibrosis (CF) pathophysiology. The focus of such studies are, however, the gut-lung axis, the intestinal microbiota, the mucus layer, or electrolyte transport. This is the first review to take into account all aspects of the intestinal barrier (microbiota, mucus layer, intestinal epithelium, immune system) that are altered in CF and may be involved in intestinal inflammation or colorectal cancer. The present review should therefore contribute to knowledge of intestinal pathophysiology in CF and inform the management of patients with gastrointestinal manifestations of CF.
Citation	Carle C, Mittaine M, Roditis L, Laborde N, Barreau F, Mas E. Intestinal epithelium impairment in cystic fibrosis: What consequences in clinical practice? World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.121071
PDF	121071-in-press.pdf

Received	2026-03-23 00:53
Peer-Review Started	2026-03-23 00:53
First Decision by Editorial Office Director	2026-04-28 01:48
Return for Revision	2026-04-28 01:48
Revised	2026-05-18 09:14
Publication Fee Transferred
Second Decision by Editor	2026-08-07 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-10 10:04
Articles in Press	2026-08-10 10:04
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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