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Articles in Press
6/4/2026 2:04:10 AM | Browse: 0 | Download: 0
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Prominent crosstalks between perineural invasion and immunosuppressive tumor microenvironment in pancreatic ductal adenocarcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shuai Sun, Rong-Jing Zhou, Si-Lin Xiang, Ting-Ting Zhang, Jun-Jun Du, Hai-Fei Zhao, Yan-Zhen Xu, Xin Pan, Xiang-Yun He and Zhi-Bo Zuo |
| Funding Agency and Grant Number |
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| Corresponding Author |
Shuai Sun, Department of Pathology, Hangzhou Cancer Hospital, No. 34 Yanguan Lane, Shangcheng District, Hangzhou 310002, Zhejiang Province, China. sunshuai005@gmail.com |
| Key Words |
Pancreatic ductal adenocarcinoma; Perineural invasion; Tumor immune microenvironment; Metastasis; Chemotherapy |
| Core Tip |
Perineural invasion is a bidirectional program in pancreatic ductal adenocarcinoma. It is sustained by crosstalks between tumor cells, nerves, and the immunosuppressive tumor microenvironment. The cellular compartments in tumor microenvironment collectively establish an immunosuppressive perineural niche. This niche enables neural dissemination, chemotherapy resistance, and cancer-associated pain. Adrenergic and cholinergic signaling amplifies this immunosuppression. Schwann cells actively guide tumor migration along nerve trunks. Therapeutic strategies targeting the neural-immune axis hold transformative potential for pancreatic ductal adenocarcinoma management. |
| Citation |
Sun S, Zhou RJ, Xiang SL, Zhang TT, Du JJ, Zhao HF, Xu YZ, Pan X, He XY, Zuo ZB. Prominent crosstalks between perineural invasion and immunosuppressive tumor microenvironment in pancreatic ductal adenocarcinoma. World J Clin Oncol 2026; In press
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Received |
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2026-03-16 02:17 |
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Peer-Review Started |
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2026-03-16 02:18 |
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First Decision by Editorial Office Director |
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2026-04-10 09:05 |
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Return for Revision |
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2026-04-10 09:05 |
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Revised |
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2026-04-28 00:03 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-06-03 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-04 02:04 |
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Articles in Press |
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2026-06-04 02:04 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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