Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	121115
Country	Egypt

Category	Pediatrics
Manuscript Type	Systematic Reviews
Article Title	Psychobiotics in pediatric autism spectrum disorder: A systematic review of efficacy, mechanisms, and clinical translation
Manuscript Source	Invited Manuscript
All Author List	Mohammed Al-Beltagi, Nermin Kamal Saeed and Yousif M Elbeltagi
Funding Agency and Grant Number
Corresponding Author	Mohammed Al-Beltagi, Chairman, Consultant, Head, MD, PhD, Professor, Department of Pediatrics, Faculty of Medicine, Tanta University, 1 Hassan Radwan Street, Tanta 31511, Algharbia, Egypt. mbelrem@hotmail.com
Key Words	Autism spectrum disorder; Psychobiotics; Probiotics; Prebiotics; Synbiotics; Fecal microbiota transplantation; Gut–brain axis, Children
Core Tip	Microbiome-targeted therapies are emerging as promising adjunctive strategies for children with autism spectrum disorder, particularly in those with co-existing gastrointestinal disorders. We observed from this systematic review that probiotics and prebiotics consistently improve gastrointestinal symptom severity, while synbiotics may provide broader modulation of gut microbial ecology. Fecal microbiota transplantation induced the largest observed improvements in both gastrointestinal outcomes and selected behavioral domains, although current evidence is limited by small sample sizes and methodological heterogeneity. These findings support strong evidence that the microbiota-gut-brain axis is a biologically reasonable therapeutic target and highlight the need for large, well-designed randomized trials.
Citation	Al-Beltagi M, Saeed NK, Elbeltagi YM. Psychobiotics in pediatric autism spectrum disorder: A systematic review of efficacy, mechanisms, and clinical translation. World J Clin Pediatr 2026; In press

Received	2026-03-16 03:37
Peer-Review Started	2026-03-16 03:38
First Decision by Editorial Office Director	2026-04-23 08:59
Return for Revision	2026-04-23 08:59
Revised	2026-04-28 10:26
Publication Fee Transferred
Second Decision by Editor	2026-05-26 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-26 06:12
Articles in Press	2026-05-26 06:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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