Publication Name	World Journal of Stem Cells
Manuscript ID	121124
DOI	10.4252/wjsc.121124
Country	China

Category	Cell Biology
Manuscript Type	Retrospective Study
Article Title	Stem/progenitor cell-driven immune microenvironment remodeling in sepsis-associated acute respiratory distress syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Xing Li, Si-Cong Jiang, Sheng-Li Fan, Yu-Xuan Xing and Lei Gong
Funding Agency and Grant Number
Corresponding Author	Lei Gong, PhD, Department of Esophageal Cancer, Tianjin Medical University Cancer Institute and Hospital, Huanhu West Road, Hexi District, Tianjin 300060, China. pear0721@163.com
Key Words	Sepsis; Acute respiratory distress syndrome; Alveolar epithelial type II cells; Progenitor cells; Inflammatory factors; Lactic acid; Prognosis
Core Tip	In sepsis-acute respiratory distress syndrome, the downregulation of alveolar epithelial type II cells progenitor markers (surfactant protein C, epithelial cell adhesion molecule) is accompanied by T-cell subset imbalance and elevated proinflammatory cytokines, which are closely associated with disease severity, oxygenation impairment and increased lactate; surfactant protein C and sequential organ failure assessment score are independent predictors of 28-day mortality, suggesting that stem/progenitor cell-mediated immune microenvironment remodeling may serve as a promising prognostic indicator and therapeutic target for sepsis-acute respiratory distress syndrome.
Citation	Li WX, Jiang SC, Fan SL, Xing YX, Gong L. Stem/progenitor cell-driven immune microenvironment remodeling in sepsis-associated acute respiratory distress syndrome. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.121124
PDF	121124-in-press.pdf

Received	2026-04-10 09:57
Peer-Review Started	2026-04-10 09:57
First Decision by Editorial Office Director	2026-04-27 09:24
Return for Revision	2026-04-27 09:24
Revised	2026-05-12 04:44
Publication Fee Transferred	2026-05-15 07:20
Second Decision by Editor	2026-06-12 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-22 09:13
Articles in Press	2026-06-22 09:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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