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Publication Name World Journal of Gastroenterology
Manuscript ID 121133
DOI 10.3748/wjg.121133
Country China
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Nanotechnology for drug delivery systems in colorectal cancer: Recent developments and future prospects
Manuscript Source Unsolicited Manuscript
All Author List Zhen-Huan Yang, Quan-Li Huang, Lei Luo, Xing-Xing Wu, Shan-Wen Nie and Man-Man Xu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 82305074
Doctoral Research Fund of Henan Provincial Hospital of Traditional Chinese Medicine 2022BJSS02
Special Project on Traditional Chinese Medicine Scientific Research of Health Commission of Henan Province 2022ZY1077
Corresponding Author Man-Man Xu, MD, Department of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange Street, Xicheng District, Beijing 100053, China. manmanxu123@126.com
Key Words Nanotechnology; Colorectal cancer; Drug delivery; Tumor microenvironment; Immune
Core Tip This review systematically summarizes recent studies on diverse nano-biomaterials, which are designed for targeted and controlled drug delivery in colorectal cancer. We specifically highlight current advances in nanomedicine-based immunotherapy, focusing on targeting of immunosenescence to reprogram immunosuppression in the tumor microenvironment and improve immune checkpoint inhibitor effects. We further discuss the problems and potential of translating such nanoplatforms into clinical practice. In summary, the present work sheds new lights on those strategies for treating colorectal cancer using nanodrug delivery technology.
Citation Yang ZH, Huang QL, Luo L, Wu XX, Nie SW, Xu MM. Nanotechnology for drug delivery systems in colorectal cancer: Recent developments and future prospects. World J Gastroenterol 2026; In press
PDF 121133-in-press.pdf
Received
2026-03-26 01:37
Peer-Review Started
2026-03-26 01:37
First Decision by Editorial Office Director
2026-04-10 10:24
Return for Revision
2026-04-10 10:24
Revised
2026-05-03 16:53
Publication Fee Transferred
2026-05-18 13:07
Second Decision by Editor
2026-07-06 08:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-07-06 09:42
Articles in Press
2026-07-06 09:42
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com