Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	121145
Country	India

Category	Immunology
Manuscript Type	Editorial
Article Title	Intravenous immunoglobulin in pediatric critical care: Bridging evidence gaps and guiding rational use
Manuscript Source	Invited Manuscript
All Author List	Amit Agrawal
Funding Agency and Grant Number
Corresponding Author	Amit Agrawal, Associate Professor, Department of Pediatrics, Gandhi Medical College, Hamidia Hospital Campus, 49-B Indrapuri, B-Sector, Bhopal 462001, Madhya Pradesh, India. agrawaldramit@yahoo.co.in
Key Words	Children; Intravenous immunoglobulin; Immunomodulation; Mortality; Off-label use; Pediatric intensive care; Side effects
Core Tip	Intravenous immunoglobulin is increasingly being utilized in pediatric intensive care units for its diverse immunomodulatory effects, even beyond established indications. The study by Varadarajan et al highlights substantial off-label use with only a few adverse effects. This editorial provides a practical, evidence-based framework for the use of intravenous immunoglobulin in critically ill children, including indications, strength of evidence, and stewardship principles to guide its rational use.
Citation	Agrawal A. Intravenous immunoglobulin in pediatric critical care: Bridging evidence gaps and guiding rational use. World J Clin Pediatr 2026; In press

Received	2026-03-17 02:59
Peer-Review Started	2026-03-17 02:59
First Decision by Editorial Office Director	2026-04-15 09:05
Return for Revision	2026-04-15 09:05
Revised	2026-04-23 07:33
Publication Fee Transferred
Second Decision by Editor	2026-05-27 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-27 06:35
Articles in Press	2026-05-27 06:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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