Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	121158
Country	South Korea

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Association of claudin 18.2 expression with outcomes of ramucirumab plus paclitaxel as second-line therapy in advanced gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Mi-Ran Han, Ji Eun Shin, Sung Hee Lim, Jeeyun Lee and Seung Tae Kim
Funding Agency and Grant Number
Corresponding Author	Seung Tae Kim, PhD, Professor, Division of Hematology-Oncology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro Gangnam-Gu, Seoul 06351, South Korea. shty1@skku.edu
Key Words	Gastric cancer; Claudin 18.2; Ramucirumab; Paclitaxel; Biomarker
Core Tip	Claudin expression is an established biomarker for targeted therapy in gastric cancer; however, its clinical relevance remains uncertain. In this retrospective study, claudin expression was not associated with survival or treatment response in patients with advanced gastric cancer who were treated with ramucirumab plus paclitaxel. These findings highlight a key distinction between intrinsic tumor biomarkers and therapies targeting the tumor microenvironment. Claudin expression should not be used to guide second-line anti-angiogenic treatments, emphasizing the need for mechanism-based biomarker selection in precision oncology.
Citation	Han MR, Shin JE, Lim SH, Lee J, Kim ST. Association of claudin 18.2 expression with outcomes of ramucirumab plus paclitaxel as second-line therapy in advanced gastric cancer. World J Gastrointest Oncol 2026; In press

Received	2026-03-18 06:42
Peer-Review Started	2026-03-18 06:42
First Decision by Editorial Office Director	2026-04-10 10:09
Return for Revision	2026-04-13 11:51
Revised	2026-04-20 08:09
Publication Fee Transferred	2026-04-27 04:51
Second Decision by Editor	2026-05-13 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-13 08:06
Articles in Press	2026-05-13 08:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com