Publication Name	World Journal of Diabetes
Manuscript ID	121165
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Maternally transmitted type 2 diabetes mellitus may be associated with mitochondrial tRNAThr mutations
Manuscript Source	Unsolicited Manuscript
All Author List	Xue-Jiao Yu and Yu Ding
Funding Agency and Grant Number	Funding Agency Grant Number Quzhou Bureau of Science and Technology No.2025K044 Hangzhou Joint Fund of the Zhejiang Provincial Natural Science Foundation of China No. LHZY24H020002 Hangzhou Municipal Health Commission No. ZD20220010
Corresponding Author	Yu Ding, Associate Professor, MD, Department of Clinical Laboratory, Hangzhou First People’s Hospital, No. 261 Huansha Road, Hangzhou 310006, Zhejiang Province, China. dingyu_zj@126.com
Key Words	Type 2 diabetes mellitus; Chinese pedigree; Mitochondrial tRNAThr; Mutations; Mitochondrial dysfunction
Core Tip	This study identified three mitochondrial tRNAThr mutations – G15927A, G15930A, and A15951G – in two Han Chinese pedigrees with maternally transmitted type 2 diabetes mellitus. These mutations were associated with variable clinical phenotypes, including deafness, visual impairment, and renal failure. Functional analyses using cybrid cell lines revealed that these mutations lead to mitochondrial dysfunction, as evidenced by reduced adenosine triphosphate production, decreased mitochondrial membrane potential, lower NAD+/NADH ratio, and increased reactive oxygen species levels. Our findings highlighted tRNAThr as a mutational hotspot in mitochondrial diabetes and supported the inclusion of these mutations in genetic screening for early diagnosis and prevention of type 2 diabetes mellitus.
Citation	Yu XJ, Ding Y. Maternally transmitted type 2 diabetes mellitus may be associated with mitochondrial tRNAThr mutations. World J Diabetes 2026; In press

Received	2026-03-19 00:30
Peer-Review Started	2026-03-19 23:57
First Decision by Editorial Office Director	2026-04-23 05:52
Return for Revision	2026-04-23 05:52
Revised	2026-05-10 08:42
Publication Fee Transferred	2026-05-25 15:10
Second Decision by Editor	2026-07-03 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-03 06:08
Articles in Press	2026-07-03 06:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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