Publication Name	World Journal of Cardiology
Manuscript ID	121185
Country	Italy

Category	Ophthalmology
Manuscript Type	Minireviews
Article Title	Identifying and treating amiodarone-induced corneal deposits: When the heart saves and the cornea speaks
Manuscript Source	Invited Manuscript
All Author List	Matteo Capobianco, Simonetta Gaia Nicolosi, Francesco Cappellani, Alessandro Avitabile, Ludovica Cannizaro, Federico Visalli, Fabiana D’Esposito, Irene Gattazzo, Caterina Gagliano and Marco Zeppieri
Funding Agency and Grant Number
Corresponding Author	Marco Zeppieri, Consultant, MD, PhD, Postdoc, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Key Words	Amiodarone; Cornea verticillata; Drug-induced keratopathy; In vivo confocal microscopy; Ocular surface disease; Multidisciplinary management
Core Tip	Amiodarone therapy is classically linked to cornea verticillata, a characteristic epithelial finding detected during routine ophthalmic examination. In many patients, these changes remain asymptomatic, but in some cases they may contribute to glare, halos, or more general visual discomfort, especially when pre-existing ocular surface disease is also present. Slit-lamp biomicroscopy remains the cornerstone of diagnosis, while anterior segment optical coherence tomography and, in selected cases, in vivo confocal microscopy may provide adjunctive structural documentation. Recognizing amiodarone-related corneal findings is clinically important, not only for accurate diagnosis, but also for appropriate patient counseling, symptom-oriented management, and rational follow-up planning.
Citation	Capobianco M, Nicolosi SG, Cappellani F, Avitabile A, Cannizaro L, Visalli F, D’Esposito F, Gattazzo I, Gagliano C, Zeppieri M. Identifying and treating amiodarone-induced corneal deposits: When the heart saves and the cornea speaks. World J Cardiol 2026; In press

Received	2026-03-18 07:29
Peer-Review Started	2026-03-18 07:33
First Decision by Editorial Office Director	2026-04-15 09:11
Return for Revision	2026-04-15 09:11
Revised	2026-04-20 12:33
Publication Fee Transferred
Second Decision by Editor	2026-05-25 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-25 08:44
Articles in Press	2026-05-25 08:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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