Publication Name	World Journal of Experimental Medicine
Manuscript ID	121192
Country	Greece

Category	Endocrinology & Metabolism
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Endocrine determinants of diabetic ketoacidosis outcomes in type 2 diabetes and insights into Gymnema sylvestre actions
Manuscript Source	Unsolicited Manuscript
All Author List	Charalampos Milionis, Emmanouil Zoumakis and Ioannis Ilias
Funding Agency and Grant Number
Corresponding Author	Ioannis Ilias, Director, MD, PhD, Department of Endocrinology, Hippocration General Hospital, No. 63 Evrou Street, Athens 11527, Greece. iiliasmd@yahoo.com
Key Words	Diabetic ketoacidosis; Type 2 diabetes mellitus; Incretin axis; Glucagon-like peptide-1; Beta-cell function; Gymnema sylvestre
Core Tip	Endocrine parameters - including beta-cell reserve, incretin signaling, and glucagon dynamics - are critical but underexplored determinants of diabetic ketoacidosis (DKA) outcomes in type 2 diabetes mellitus. The concurrent occurrence of acute pancreatitis in DKA, which may affect at least 15% of cases and substantially worsens prognosis, adds diagnostic complexity by masking hallmark features of both conditions and amplifying metabolic and hormonal dysregulation. The metabolic effects of Gymnema sylvestre also require deeper hormonal characterization to clarify its mechanism of action.
Citation	Milionis C, Zoumakis E, Ilias I. Letter to the Editor: Endocrine determinants of diabetic ketoacidosis outcomes in type 2 diabetes and insights into Gymnema sylvestre actions. World J Exp Med 2026; In press

Received	2026-03-18 05:19
Peer-Review Started	2026-03-18 05:23
First Decision by Editorial Office Director	2026-03-27 10:47
Return for Revision	2026-03-27 10:47
Revised	2026-03-31 10:40
Publication Fee Transferred
Second Decision by Editor	2026-04-14 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-14 06:36
Articles in Press	2026-04-14 06:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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