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Articles in Press
6/9/2026 6:24:03 AM | Browse: 8 | Download: 0
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Regulatory effects of Dangua Fang on the NAMPT/NAD+/SIRT1 axis and amino acid metabolism in type 2 diabetic rats
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zhuang Han, Zhi-Ta Wang, Liu-Qing Yang and Xian-Pei Heng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82274389 and No. 82205071 |
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| Corresponding Author |
Xian-Pei Heng, Chief Physician, MD, PhD, Professor, Department of Endocrinology, People’s Hospital Affiliated with Fujian University of Traditional Chinese Medicine, No. 162 Bayiqi Middle Road, Taijiang District, Fuzhou 350004, Fujian Province, China. 1230757004@fjtcm.edu.cn |
| Key Words |
Traditional Chinese medicine; Dangua Fang; Type 2 diabetes mellitus; Nicotinamide phosphoribosyltransferase/nicotinamide adenine dinucleotide/sirtuin 1 axis; Amino acid metabolism; Targeted metabolomics |
| Core Tip |
This study demonstrated that Dangua Fang (DGF) ameliorated glucolipid metabolic disorders in type 2 diabetes mellitus rats. DGF reduced blood glucose and lipid levels and alleviated hepatic histopathological injury. These effects were accompanied by increased hepatic nicotinamide phosphoribosyltransferase, nicotinamide adenine dinucleotide, and sirtuin 1 expression. Metabolomic analysis further revealed that DGF significantly regulated abnormal hepatic amino acid metabolism in diabetic rats, which might be associated with modulation of the nicotinamide phosphoribosyltransferase/nicotinamide adenine dinucleotide/sirtuin 1 axis. |
| Citation |
Han Z, Wang ZT, Yang LQ, Heng XP. Regulatory effects of Dangua Fang on the NAMPT/NAD+/SIRT1 axis and amino acid metabolism in type 2 diabetic rats. World J Diabetes 2026; In press
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| PDF |
121202-in-press.pdf
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Received |
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2026-03-18 03:15 |
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Peer-Review Started |
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2026-03-23 00:06 |
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First Decision by Editorial Office Director |
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2026-05-08 11:40 |
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Return for Revision |
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2026-05-08 11:40 |
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Revised |
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2026-05-12 20:26 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-29 09:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-09 06:24 |
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Articles in Press |
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2026-06-09 06:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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